TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 40

Pharmaceutical Substances Syntheses, Patents, Applications - Part 40. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Cefotiam C 391 COOH O 7 S -bromoacetamido- 7-methaxycephalo- sporanic acid pH ------------ COOH 0 NoHC03 n _N- ---------- HS CH3 1-methyl--1H-tetrazale-5-thiol Reference s DOS 2 824 559 Yamanouchi appl. . . US4263 432 Yamanouchi appl. J-prior. . Formulation s vial 250 mg 500 mg 1 g 2 g as sodium salt Trade Name s D Apatef ICI 1985 wfm I Apatef Zeneca J Yamatetan Yamanouchi F Apacef Zeneca Cepan IBI USA Cefotan Stuart 1986 Cefotiam ATC JO IDA 19 Use antibiotic RN 61622-34-2 MF C18H23N9O4S3 MW LD50 3840 mg kg M . CN 6R- rans -7- 2-amino-4-thiazolyl acetyl amino -3- l- 2- dimethylamino ethyl -l 7-tetrazol-5-yl thio methyl -8-oxo-5-thia-l-azabicyclo oct-2-ene-2-carboxylic acid dihydrochloride RN 66309-69-1 MF C18H23N9O4S3 2HC1 MW CH 1. NaHC03 pH 7 60-65 C 2. NH2OH-HCI pH 1 - 2-dimethyl-ominoethyl -1 H-tetrazole-5-thiol 7-ocetoacetamidocephalosporanic acid 392 c Cefoxitin L N-OH dcc n c2h5 3 ch2ci2 ---------------- ------------- N-hydroxysuccinimide Cefotiom 2-amino-4-thiozoleocetic acid hydrochloride Reference s Tsushima S. et al. Chem. Pharm. Bull. CPBTAL 27 696 1979 . DOS 2 461 478 Takeda appl. J-prior. . DAS 2 462 736 Takeda appl. J-prior. . US 4 080 498 Takeda appl. J-prior. . DE 2 738 711 Takeda appl. J-prior. . US 4 146 710 Takeda J-prior. . intermediates DOS 2 607 064 Takeda appl. J-prior. . Formulation s vial 500 mg 1 g 2 g as dihydrochloride tabl. 100 mg 200 mg Trade Name s D Spizef Takeda 1982 F Taketiam Takeda Texodil Cassenne I Sporidyn Zoja J Pansporin T Takeda 1981 Sporidyn Cyanamid Cefoxitin ATC J01DA05 Use antibiotic RN 35607-66-0 MF C16H17N3O7S2 MW EINECS 252-641-2 LD50 4970 mg kg M . 10 g kg M . 8580 mg kg R . 10 g kg R . 10 g kg dog . CN 6R-c s -3- aminocarbonyl oxy methyl -7-methoxy-8-oxo-7- .

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