TAILIEUCHUNG - HPLC for Pharmaceutical Scientists 2007 (Part 13)

Recent advances in mass spectrometry have rendered it an attractive and versatile tool in industrial and academic research laboratories. As a part of this rapid growth, a considerable body of literature has been devoted to the application of mass spectrometry in clinical studies. In concert with separation techniques such as liquid chromatography, mass spectrometry allows the rapid characterization and quantitative determination of a large array of molecules in complex mixtures. Herein, we present an overview of the above techniques accompanied with several examples of the use of liquid chromatography– tandem mass spectrometry in pharmacokinetics/drug metabolism assessment during drug. | 13 THE ROLE OF LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY IN PHARMACOKINETICS AND DRUG METABOLISM Ray Bakhtiar Tapan K. Majumdar and Francis L. S. Tse INTRODUCTION Recent advances in mass spectrometry have rendered it an attractive and versatile tool in industrial and academic research laboratories. As a part of this rapid growth a considerable body of literature has been devoted to the application of mass spectrometry in clinical studies. In concert with separation techniques such as liquid chromatography mass spectrometry allows the rapid characterization and quantitative determination of a large array of molecules in complex mixtures. Herein we present an overview of the above techniques accompanied with several examples of the use of liquid chromatographytandem mass spectrometry in pharmacokinetics drug metabolism assessment during drug development. Since the evolution of pharmaceutical research 1 2 the stages of drug discovery and development have followed three predominant patterns i the systematic and methodical approach by chemists to rationally design and synthesize a molecule to target a specific molecular system . ion channels receptors enzymes DNA ii the isolation and purification of the active ingredients of medicinal plants or microorganisms to screen their spectrum of HPLC for Pharmaceutical Scientists Edited by Yuri Kazakevich and Rosario LoBrutto Copyright 2007 by John Wiley Sons Inc. 605 606 THE ROLE OF LC-MS IN PK AND DRUG METABOLISM activity using in vitro models or iii the serendipitous discovery of a compound with a novel pharmacological action . the accidental discovery of antidepressants . Today one of the increasingly popular and complementary approaches for drug discovery in the pharmaceutical industry is to perform massive parallel synthesis in solution or on a solid support. In addition with the advent of functional genomics and proteomics cell-based assays and molecular biology a multitude of therapeutic targets have been .

• Y học thường thức
• drug metabolism
• HPLC
• Pharmaceutical Scientists 2007
• HPLC Theory
• tài liệu chuyên ngành dược
• sách học dược sĩ
• Drug–drug interaction
• Possible drug–drug interaction
• Dogs and cats resulted
• Alteration in drug metabolism
• of Drug Metabolism
• Drug Metabolite
• Quantitative Drug Metabolism
• Development Processes
• Drug Discovery
• Medicinal Chemistry
• Animal models
• Drug metabolising enzymes
• First pass oral clearance
• Gut wall metabolism
• Oral bioavailability
• BMC Pharmacology and Toxicology
• CYP3A4 activity
• Inflammatory biomarkers
• Undergoing maintenance hemodialysis
• Cationic liposomes
• RNA seq
• Lipid metabolism
• Non viral vectors
• Drug delivery
• Therapeutics
• Mechanisms
• Drug Action
• Calcium Channel
• Diuretic Drugs
• Antihypertensive Drugs
• Central Nervous System
• Pharmacology
• Medical pharmacology at a glance
• Drug absorption
• Local anaesthetics
• Autonomic nervous system
• Drugs acting on the sympathetic system
• Ocular pharmacology
• BMC Chemistry
• Sites of metabolism
• Reaction SMARTS patterns
• 2D fingerprint similarity
• Drug like molecules
• BMC Cancer
• Tamoxifen metabolism
• Drug drug interaction
• Undergoes bioactivation
• Anti cancer drugs
• General and molecular pharmacology
• Molecular pharmacology
• Essential lexicon
• A short history of pharmacology
• Cytochrome P450
• TaqMan PCR
• Dried saliva
• Japanese population
• Genetic analysis
• Emerging Risks
• Xenotropic Murine
• Leukemia Virus Related
• Blood Borne Pathogens
• Ultrafine and Fine Aerosol
• Safety
• Scientific reports
• scientific research
• biochemistry
• biochemical studies
• environmental medicine
• Crystal structure
• báo cáo khoa học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• Human Immunodeficiency Virus
• Hepatitis B
• Hepatitis C
• Non Injecting Drug
• City Neighborhoods
• Isolator System
• trình bày báo cáo
• tài liệu báo cáo khoa học
• nghiên cứu y học
• báo cáo y học
• kiến thức y học
• Ovarian cancer
• Hematologic toxicities
• Single nucleotide polymorphisms
• Platinum could predict toxicity
• BMC Pediatrics
• Kidney transplantation
• Acute rejection
• Children undergoing renal transplantation
• Cytidine deaminase
• Pancreatic adenosquamous carcinoma
• Guide optimal treatment
• Drug combination
• Cancer therapy
• Nutlin 3
• PDH activation
• Cell lines
• Colorectal cancer cells
• Drug resistance
• Minimal side effects
• Targeting cancer cells
• Clinical medicine
• Cardiovascular disease
• Respiratory disease
• Intensive care medicine
• Drug therapy
• Endocrine disease
• Other disorders of metabolism
• Essentials of pharmaceutical chemistry
• Pharmaceutical chemistry
• Chemistry of acids
• Chemistry of bases
• Partition coefficient