TAILIEUCHUNG - The prevalence and prognostic impact of tumor-infiltrating lymphocytes in uterine carcinosarcoma

To examine the prevalence and prognostic role of tumor microenvironment (TME) markers in uterine carcinosarcoma (UCS) through immunohistochemical characterization. Methods: The internal database of our institution was queried out for women with UCS who underwent surgery and thereafter postoperative chemotherapy with carboplatin and paclitaxel between January 2012 and December 2017. | da Silva et al. BMC Cancer 2021 21 1306 https s12885-021-09026-6 RESEARCH Open Access The prevalence and prognostic impact of tumor-infiltrating lymphocytes in uterine carcinosarcoma Jesse Lopes da Silva1 2 Lucas Zanetti de Albuquerque1 Fabiana Resende Rodrigues3 Guilherme Gomes de Mesquita1 3 Cláudia Bessa Pereira Chaves1 2 Martín Hernán Bonamino4 5 and Andreia Cristina de Melo1 Abstract Objective To examine the prevalence and prognostic role of tumor microenvironment TME markers in uterine carcinosarcoma UCS through immunohistochemical characterization. Methods The internal database of our institution was queried out for women with UCS who underwent surgery and thereafter postoperative chemotherapy with carboplatin and paclitaxel between January 2012 and December 2017. Tissue microarrays containing surgical samples of UCS from 57 women were assessed by immunohistochemistry for CD3 CD4 CD8 FOXP3 PD-1 PD-L1 and PD-L2. Results The mean age was years range 49 to 79 years . For the epithelial component E CD3_E and CD4_E were highly expressed in 38 and in 40 patients respectively and were significantly associated with more advanced stages p and p respectively . CD8_E was highly expressed in 42 patients FOXP3_E 16 PD-1_E 35 PD-L1_E 27 and PD-L2_E 39 . For the sarcomatous compo- nent S the prevalence of high expression was CD3_S 6 CD4_S 20 CD8_S 44 FOXP3_S 8 14 PD-1_S 14 PD-L1_S 14 and PD-L2_S 8 14 . By multivariate analysis the CD8 FOXP3_S ratio p CD4_E p PD-L1_E p and PD-L1_S p markers significantly influenced progres- sion-free survival. CD4 FOXP3_S ratio p PD-1_E p PD-L1_E p and PD-L1_S p had a significant association with overall survival. Conclusion Some differences in UCS clinical outcomes may be due to the subtype of TILs and PD-1 PD-L1 axis immune checkpoint signaling. Keywords Uterine carcinosarcoma Tumor-infiltrating .

• Y khoa - Dược
• BMC Cancer
• Uterine carcinosarcoma
• Tumor infltrating lymphocyte
• Tumor microenvironment
• Immune biomarkers
• Tumor microenvironment
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study