TAILIEUCHUNG - Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: A multicenter study from China

At present, hepatectomy is still the most common and efective treatment method for intrahepatic cholangiocarcinoma (ICC) patients. However, the postoperative prognosis is poor. Therefore, the prognostic factors for these patients require further exploration. Whether microvascular invasion (MVI) plays a crucial role in the prognosis of ICC patients is still unclear. | Chen et al. BMC Cancer 2021 21 1299 https s12885-021-09035-5 RESEARCH Open Access Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma a multicenter study from China Yifan Chen1 Hongzhi Liu1 Jinyu Zhang1 Yijun Wu1 Weiping Zhou2 Zhangjun Cheng3 Jianying Lou4 Shuguo Zheng5 Xinyu Bi6 Jianming Wang7 Wei Guo8 Fuyu Li9 Jian Wang10 Yamin Zheng11 Jingdong Li12 Shi Cheng13 Yongyi Zeng1 14 and Jingfeng Liu1 Abstract Background At present hepatectomy is still the most common and effective treatment method for intrahepatic cholangiocarcinoma ICC patients. However the postoperative prognosis is poor. Therefore the prognostic factors for these patients require further exploration. Whether microvascular invasion MVI plays a crucial role in the prognosis of ICC patients is still unclear. Moreover few studies have focused on preoperative predictions of MVI in ICC patients. Methods Clinicopathological data of 704 ICC patients after curative resection were retrospectively collected from 13 hospitals. Independent risk factors were identified by the Cox or logistic proportional hazards model. In addition the survival curves of the MVI-positive and MVI-negative groups before and after matching were analyzed. Subsequently 341 patients from a single center Eastern Hepatobiliary Hospital in the above multicenter retrospective cohort were used to construct a nomogram prediction model. Then the model was evaluated by the index of concordance C-Index and the calibration curve. Results After propensity score matching PSM Child-Pugh grade and MVI were independent risk factors for overall survival OS in ICC patients after curative resection. Major hepatectomy and MVI were independent risk factors for recurrence-free survival RFS . The survival curves of OS and RFS before and after PSM in the MVI-positive groups were significantly different compared with those in the MVI-negative groups. Multivariate logistic regression

• Y khoa - Dược
• BMC Cancer
• Intrahepatic cholangiocarcinoma
• Microvascular invasion
• Prediction model
• Prognostic factors
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study