TAILIEUCHUNG - METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-meth‑ yladenosine (m6 A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully elucidated. | Zhuo et al. BMC Cancer 2021 21 1294 https s12885-021-09019-5 RESEARCH Open Access METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children Zhenjian Zhuo1 Rui Xi Hua1 Huizhu Zhang2 Huiran Lin3 Wen Fu1 Jinhong Zhu4 Jiwen Cheng5 Jiao Zhang6 Suhong Li7 Haixia Zhou8 Huimin Xia1 Guochang Liu1 Wei Jia1 and Jing He1 Abstract Background Wilms tumor is a highly heritable malignancy. Aberrant METTL14 a critical component of N6-meth yladenosine m6A methyltransferase is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully elucidated. We aimed to assess whether variants within this gene are implicated in Wilms tumor susceptibility. Methods A total of 403 patients and 1198 controls were analyzed. METTL14 genotypes were assessed by TaqMan genotyping assay. Result Among the five SNPs analyzed rs1064034 T gt A and rs298982 G gt A exhibited a significant association with decreased susceptibility to Wilms tumor. Moreover the joint analysis revealed that the combination of five protective genotypes exerted significantly more protective effects against Wilms tumor than 0 4 protective genotypes with an OR of . The stratified analysis further identified the protective effect of rs1064034 T gt A rs298982 G gt A and combined five protective genotypes in specific subgroups. The above significant associations were further validated by haplotype analysis and false-positive report probability analysis. Preliminary mechanism exploration indicated that rs1064034 T gt A and rs298982 G gt A are correlated with the expression and splicing event of their surrounding genes. Conclusions Collectively our results suggest that METTL14 gene SNPs may be genetic modifiers for the develop ment of Wilms tumor. Keywords Wilms tumor Risk METTL14 Polymorphism Case-control study Introduction per million children in the United States. Wilms tumor is Wilms tumor also known as .

• Y khoa - Dược
• BMC Cancer
• Wilms tumor
• Case control study
• N6 methyladenosine
• METTL14 gene
• False positive report probability analysis
• Surrounding genes
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study