TAILIEUCHUNG - Characteristics of white adipose tissue shape and weight in the restricted high fat diet fed mice

Our data suggest that a restricted high-fat diet feeding shows an obvious effect on the change of body weight as well as on the alteration of adipose tissue size and weight. Hence, the restricted high-fat diet feeding may be used as a promise method to induce obese model at least partly in mouse. | HNUE JOURNAL OF SCIENCE DOI Natural Sciences 2018 Volume 63 Issue 11 pp. 142-146 This paper is available online at http CHARACTERISTICS OF WHITE ADIPOSE TISSUE SHAPE AND WEIGHT IN THE RESTRICTED HIGH-FAT DIET-FED MICE Le Ngoc Hoan1 Nguyen Phuc Hung1 Ho Thi Hong Van2 and Chu Dinh Toi1 1 Faculty of Biology Hanoi National University of Education 2 Vietnam Institute of Educational Science Abstract. Obesity is associated with changes not only in tissue function but also in tissue morphology. We previously reported that arbitrarily high-fat diet feeding induced some moderate alterations in metabolic tissues. Here we show that restricted high-fat diet feeding mice for 30 days led to a markedly increase in body weight. This was accompanied by strongly changes in gross morphology and weights of several white adipose tissues including subcutaneous axillary and epididymal adipose tissues. Our data suggest that a restricted high-fat diet feeding shows an obvious effect on the change of body weight as well as on the alteration of adipose tissue size and weight. Hence the restricted high-fat diet feeding may be used as a promise method to induce obese model at least partly in mouse. Keywords High-fat diet restricted feeding body weight tissue weight. 1. Introduction Obesity is increasing as worldwide epidemic 1 . Obesity is a condition which is usually accompanied by metabolic dysfunctions in humans such as nonalcoholic fatty liver diseases cardiovascular diseases type 2 diabetes and certain cancers 2 . There are evidences supporting that increased adipogenesis of white adipose tissues may contribute to increases in those metabolic malfunctions. Adipose tissues can also secrete cytokines such as monocyte chemoattractant protein MCP -1 who attracts the migration of immune cells. Then the cross-talk between the migrated cells and local cells induced not only dysfunctions of the local tissues but also dysfunction of whole body 3 . Thus

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