TAILIEUCHUNG - Antidiabetic and antihypertensive properties of chymotrypsin treated cow milk casein

The metabolic activities of the casein peptides were verified using purified enzymatic inhibition studies. The regulatory enzyme inhibition led us to conclude a positive correlation with the role of casein peptides in modulating the diabetic and hypertensive metabolic pathways in the biological system. Purified enzymes were used for the investigation to clearly observe the direct impact on the diabetes and hypertension related bioprocesses. In the current study, the effect of chymotrypsin treatment was also investigated on the casein hydrolysates and their effects on regulatory metabolic enzymes were further analyzed. | 2020 9 6 1246-1255 International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 9 Number 6 2020 Journal homepage http Original Research Article https Antidiabetic and Antihypertensive Properties of Chymotrypsin Treated Cow Milk Casein Santosh Kumar1 SumanKumari2 Vipan Kumar3 and Deepak Kumar4 1 MDETT Research Center BAIF Development Research Foundation Dharoli Jind 126113 Haryana India 2 Dolphin PG Institute of Biomedical amp Natural Sciences Dehradun Uttarakhand India 3 Department of Veterinary Microbiology Khalsa College of Veterinary and Animal Science Amritsar Punjab India 4 Department of Pharmaceutical Chemistry Dolphin PG Institute of Biomedical amp Natural Sciences Dehradun Uttarakhand India Corresponding author ABSTRACT Milk is known to contain a number of peptides fractions that affect metabolic responses. Keywords Casein being the most abundant milk protein after enzymatic treatment generates peptide fragments which have unique ability to regulate the diabetic and hypertensive metabolic Angiotensin pathways in the biological system. Upon oral administration of bioactive peptides may converting affect the major body system-namely the cardiovascular digestive immune and nervous enzyme ACE systems showing multiple biogenic effects such as antimicrobial Immuno modulatory Amylase Antihypertensive antioxidative antithromboic antidiabetic and antihypertensive. In the present study the Imunomodulation peptide formulation derived from chymotrypsin treated cow milk casein was functionally Biogenic peptides studied for their antidiabetic via α-amylase inhibition and antihypertensive via angiotensin converting enzyme inhibition activity. The peptide content and their biogenic Article Info effects varies with the duration of enzymatic treatment thus depicting variable effects. Maximum antidiabetic effect was shown by bioactive derived after 3 hours of .

• Nông nghiệp
• Angiotensin converting enzyme
• Biogenic peptides
• Chymotrypsin treated cow milk casein
• Antihypertensive properties
• Regulatory metabolic enzymes
• BMC Cancer
• Esophageal cancer
• Gastric cancer
• Angiotensin converting enzyme inhibitors
• Angiotensin receptor blockers
• Survival analysis
• Angiotensin converting enzyme inhibitory activity
• Vietnamese medicinal plants
• Angiotensin 1 converting enzyme
• Leea rubra
• Uncaria sessilifructus
• Goat milk
• Bioactive peptides
• Angiotensin I converting enzyme
• Anti hypertension
• Proteins of goat milk
• Hepatocellular carcinoma
• High risk cohort
• Comparative effectiveness
• Angiotensin II receptor blockers
• medical research
• Angiotensin Converting
• Enzyme
• Coronary Artery Disease
• therapeutic
• pharmaceutical
• scientific reports
• treatment
• symptoms
• biochemical
• Angiotensin converting enzyme inhibitory
• Antibacterial activities of low molecular weight peptides derived
• Spent brewer’s yeast
• Low molecular weight peptide
• Spent brewer's yeast
• Hypertensive nephropathy
• Renin angiotensin system
• Dihydroflavone family
• Hypertensive kidney damage
• BMC Pharmacology and Toxicology
• Diabetes mellitus
• Chronic kidney disease
• Reninangiotensin system
• Pancreatic cancer
• Randomized clinical trials
• Maternal fetal transfer
• Milk secretion
• Angiotensin receptor blocker
• trình bày báo cáo
• tài liệu báo cáo khoa học
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• nghiên cứu y học
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• công trình nghiên cứu về y học
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• cách trình bày báo cáo
• chuyên ngành y khoa
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• bài giảng y học
• bệnh lâm sàng
• chuẩn đoán bệnh
• medical report
• scientific research
• Crystal structure
• medical analysis
• biochemical studies
• Report medicine
• traditional medicine
• Structural biochemistry
• bacteria
• chemical reaction
• oxidation
• immune system
• Antimicrobial
• biosynthesis
• environmental medicine
• medical knowledge
• analysis of cytoplasmic
• First attack
• Acute angioedema
• Significant predictive factors
• Acute angioedema in children
• BMC Pulmonary Medicine
• Genetic modulation
• Cystic fibrosis
• Modifier genes
• CFTR genotype
• Severe acute respiratory syndrome coronavirus 2
• Life threatening COVID 19
• Potential protective mechanisms