TAILIEUCHUNG - Synthesis of 1, 3-diaryl-2-propene-1-one derivatives using Tripotassium phosphate as an alternative and efficient catalyst and study its cytotoxic and antimicrobial properties

A series of fourteen chalcone was synthesized via. Claisen–Schmidt condensation between substituted 2- hydroxyl acetonaphthones and substituted benzaldehyde in presence of tripotassium phosphate (K3PO4) catalyst. | Synthesis of 1 3-diaryl-2-propene-1-one derivatives using Tripotassium phosphate as an alternative and efficient catalyst and study its cytotoxic and antimicrobial properties Current Chemistry Letters 9 2020 183 198 Contents lists available at GrowingScience Current Chemistry Letters homepage Synthesis of 1 3-diaryl-2-propene-1-one derivatives using Tripotassium phosphate as an alternative and efficient catalyst and study its cytotoxic and antimicrobial properties Pravinkumar Patila Pathan Amjad Khana and Sainath Zangadeb a Research Laboratory Department of Chemistry . Science College Nanded-431605 M S India b Department of Chemistry Madhavrao Patil ACS College Palam Dist. Parbhani-431720 M S India CHRONICLE ABSTRACT Article history A series of fourteen chalcone was synthesized via. Claisen Schmidt condensation between Received October 26 2019 substituted 2- hydroxyl acetonaphthones and substituted benzaldehyde in presence of tripotassium Received in revised form phosphate K3PO4 catalyst. The reaction was carried out by conventional method using 2- February 25 2020 methoxyethanol. The procedure is simple and efficient in terms of reaction time easy workup and Accepted March 23 2020 isolation of products and yields. In-vitro all these synthesized compounds were screened and Available online March 23 2020 evaluated for the cytotoxic and antimicrobial activity. It was found that these compounds had significant cytotoxic activity in comparison with standard 5-flurouracil. The compounds 3a 3b 3h Keywords 3f and 3l were screened by MTT assay against liver cancer cell line-HepG2. Among these the Synthesis compound 3b and 3c showed LC50 values of μM ml and μM ml. respectively. The Chalcones remaining compounds did not display the LC50 values. The compound 3l displayed the strongest Tripotassium phosphate cytotoxic activities with IC50 value of μg ml against liver cancer cell line. The Chalcone 3a 2-Methoxyethanol 3f 3h and

• Hoá học
• 1 3 diaryl 2 propene 1 one
• Claisen–Schmidt condensation
• 2 hydroxyl acetonaphthones
• Tripotassium phosphate catalyst
• Cytotoxic and antimicrobial properties
• Journal of Chemistry
• Phlomis linearis
• Essential oil
• Liquid chromatography mass spectromtetry (LC MS/MS)
• Gas chromatography mass spectrometry
• Chemical composition
• Biological activities