TAILIEUCHUNG - Design, synthesis and biological evaluation of 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaffold as antimicrobial and antioxidant candidates

A series of semicarbazones, thiosemicarbazones, 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaffold were designed and synthesized. All the synthesized new compounds were characterized by 1H NMR, 13C NMR, MS and elemental analysis. | Design synthesis and biological evaluation of 1 3 4-oxadiazoles thiadiazoles bearing pyrazole scaffold as antimicrobial and antioxidant candidates Current Chemistry Letters 5 2016 109 122 Contents lists available at GrowingScience Current Chemistry Letters homepage Design synthesis and biological evaluation of 1 3 4-oxadiazoles thiadiazoles bearing pyrazole scaffold as antimicrobial and antioxidant candidates Pavithra Gurunanjappa and Ajay Kumar Kariyappa Post Graduate Department of Chemistry Yuvaraja s College University of Mysore Mysuru 570005 India CHRONICLE ABSTRACT Article history A series of semicarbazones thiosemicarbazones 1 3 4-oxadiazoles thiadiazoles bearing Received October 21 2015 pyrazole scaffold were designed and synthesized. All the synthesized new compounds were Received in revised form characterized by 1H NMR 13C NMR MS and elemental analysis. The synthesized compounds December 20 2015 were screened to probe their in vitro antimicrobial activity against bacteria and fungi species. Accepted 12 Februray 2016 The structure-activity relationship of the synthesized compounds was studied. The compounds Available online displayed good to excellent potency against tested microorganisms. The in vitro antioxidant 12 February 2016 activities of the 1 3 4-oxadiazoles thiadiazoles were evaluated by DPPH hydroxyl and nitric Keywords oxide radical scavenging assay. Among the tested compounds compound with chloro Antimicrobial Antioxidant substitution showed good antioxidant potential. Pyrazole Semicarbazone Thiosemicarbazone 2016 Growing Science Ltd. All rights reserved. 1. Introduction The pyrazole motif makes up the core structure of numerous biologically active compounds. Compounds bearing pyrazole nucleus exhibit versatile range of biological activities such as antimicrobial1 anti-inflammatory2 analgesic3 and GABA receptor antagonists and In addition to the diverse biological activities of pyrazoles other heterocycles

• Hoá học
• Design synthesis and biological
• Series of semicarbazones
• Oxadiazoles/thiadiazoles bearing pyrazole scaffold
• Antimicrobial and antioxidant candidates
• In vitro antioxidant activities
• BMC Chemistry
• Biological evaluation
• Biological potential
• Antimicrobial potential
• Antimicrobial screening
• Chemical and Biological science
• Least squares
• Box Hunter design
• Reponse surface design
• Central composite design
• 2 Mercaptobenzimidazole
• Biological profile
• Heterocyclic benzimidazole analogues
• Prospective antimicrobial
• Anti proliferative agents
• Anticancer activities
• Thiourea derivatives
• Exhibited biological activities
• Benzenesulfonamide derivatives
• Biological activity
• Glycyrrhetinic acid
• Cinnamic acid
• Anti tumor
• Combination principle
• Benzoxazole molecules
• Antimicrobial activity
• Anticancer activity
• Biological activities
• Phenazine 1 carboxylic acid
• Salicylic acid
• Fungicidal activities
• 2 aminooxazol 5 yl
• Oxazole analogues
• Carbon NMR
• Synthesized oxazole
• Antiproliferative activities
• Report medicine
• traditional medicine
• scientific reports
• intermediate cells
• cell proliferation
• medical analysis
• p Amino benzoic acid
• 2 Mercaptobenzimidazole derivatives
• Dihydrofolate reductase
• Purine nucleotides
• Chlorogenic acid
• Urease inhibition
• Anti H pylori
• Therapeutic agent
• Bis pyrimidines
• Claisen–Schmidt condensation
• Minimum inhibitory concentration
• Gram positive bacterium
• Bacillus subtilis
• Escherichia coli
• Pseudomonas aeruginosa
• Klebsiella pneumoniae
• Molecular docking
• Structure–activity relationship
• DHFR inhibitors
• Sulfonamides conjugated
• Catalpol propionate
• Antiaging drug
• Surflex Docking method
• Pyrimidine derivatives
• Antioxidant and anticancer activity
• Biginelli condensation
• Substituted aldehyde
• 3D7 strain
• Pharmacological actions
• Journal of Chemistry
• PARP inhibitors
• Thin layer chromatography
• High performance liquid chromatography
• Elemental analysis
• Anti tyrosinase agents
• Structure based design
• Kinetic study