TAILIEUCHUNG - One-pot multi-component green synthesis of highly substituted piperidines

An effective and expeditious method of the synthesis of a highly functionalized piperidines, catalyzed by nontoxic, recyclable and environment friendly sodium lauryl sulfate (SLS), via one-pot multi-component condensation of aldehydes, amines and β-ketoesters in water at room temperature, has been developed. | One-pot multi-component green synthesis of highly substituted piperidines Current Chemistry Letters 6 2017 135 142 Contents lists available at GrowingScience Current Chemistry Letters homepage One-pot multi-component green synthesis of highly substituted piperidines Ravi Bansal Pradeep K. Soni Jyoti Sharma Santosh K. Bhardwaj and Anand K. Halve School of Studies in Chemistry Jiwaji University Gwalior . INDIA- 474011 CHRONICLE ABSTRACT Article history An effective and expeditious method of the synthesis of a highly functionalized piperidines Received January 2 2017 catalyzed by nontoxic recyclable and environment friendly sodium lauryl sulfate SLS via Received in revised form one-pot multi-component condensation of aldehydes amines and β-ketoesters in water at room March 1 2017 temperature has been developed. This new protocol has advantages such as moderate to high Accepted March 6 2017 yields of products obtained after simple post reaction workup. Structure of the synthesized Available online compounds 4a 4j have been elucidated based on the 1H NMR 13C NMR FT-IR spectroscopy March 6 2017 and elemental analysis. Keywords Heterocycles Piperidines Multi-component synthesis Catalyst Sodiumlaurylsulfate SLS 2017 Growing Science Ltd. All rights reserved. 1. Introduction Heterocyclic compounds containing nitrogen atom are wide spread in nature and have significant practical importance because of their applications in medicine and 2 They are also used as functional materials. The development of new and efficient methods for the synthesis of N-heterocycles is one of the greater interests of modern synthetic organic Synthesis of complex heterocyclic molecules can be easily achieved starting from readily available starting materials in a single step multi-component reactions MCRs .6 In most of the cases these reactions are advantageous over the linear step-wise syntheses because of the operational simplicity shorter .

• Hoá học
• Multi component synthesis
• Catalyzed by nontoxic
• Environment friendly sodium lauryl sulfate
• One pot multi component condensation
• Highly substituted piperidines
• BMC Chemistry
• Multicomponent synthesis
• Mechanochemical synthesis
• Atom economy
• Yield economy
• Antibacterial activity
• Antifungal property
• Antioxidant efect
• Journal of Chemistry
• Organic salts
• 2 hydroxy 1 4 naphthoquinone
• Crystal structure
• Hydrogen bonds
• One pot multicomponent reaction
• Microwave irradiation
• Multicomponent reactions
• One pot synthesis
• Green synthesis
• Catalyst free microwave
• Knoevenagel condensation reaction
• KOH loaded CaO
• 4H pyran derivatives
• Solvent free condition
• Antitumor activity
• Mannich base
• Multicomponent reaction
• Methylene tethered tetrahydroquinolines
• Diastereoselective synthesis
• 2 5 dioxopyrrolidine derivatives
• Biocatalytic reactions
• Green specifications
• Thioformamide derivatives
• Environmentally green synthesis
• Multicomponent reactions (MCRs)
• Mesoionic rhodanine
• Less Systems
• Multicomponent Systems
• Grain Morphologies
• Ceramic Powders
• Stereolithography Process
• Ceramic Composites
• N bromosuccinimde catalyzed
• One pot condensation
• One pot multicomponent condensation reaction
• By product N succinimide
• Environmentally benign chemical processe
• Domino reactions
• Chemo divergent multicomponent reactions
• Antiproliferative activity
• Apoptosis induction
• Nickel ferrite
• Magnetic nanoparticles
• 4H chromenes
• Green methodology
• p TSA
• Benzo[a]pyrimido[5’
• 4’:5
• 6]pyrido[2
• 3 c ]phenazine
• Microwave assisted organic
• Antiinflammatory activities
• Multicomponent domino reactions
• Green chemistry
• Benzo[a]chromeno[2 3 c]phenazine
• Aromatic aldehydes
• 6 aryl 3 oxo 2
• 3 dihydropyridazine 4 carbohydrazide derivatives
• Diversity oriented construction
• 6 arylpyridazinone skeleton
• Cyclic enaminones
• α β unsaturated nitriles
• Spirooxindole derivatives
• Hexahydroquinoline derivatives
• Copper catalyst
• 1 2 3 triazoles
• Cyclic voltammetry
• ICP AES spectroscopic techniques
• Antimicrobial action
• Toxicity analysis
• Multicomponent nanomaterials
• Metal supported nanomaterials
• Furan fused compounds
• Ammonium acetate
• Tạp chí khoa học
• Khoa học tự nhiên
• Mannich reaction
• Multicomponent condensation reaction
• Azacrown ether
• Ultrasound accelerated arylthiomethylation
• Mannich type reactions
• Magnetic stirring and ultrasonic irradiation
• The mechanism and process
• Mannich type reactions in the synthesis
• N heterocyclic carbene
• Dinuclear complex
• Organometallic chemistry
• Dibenzimidazolium salts
• 5 Acetylimidazole
• Anticancer activity
• 3 cyanopyridine derivative
• 1 3 4 oxadiazoles
• Trichloroacetyl isocyanate
• (N isocyanimino)triphenylphosphorane
• Aza Wittig