TAILIEUCHUNG - Assessment of selected hepatic serum enzymes in contaminated crude-oil feeds on albino wistar rats

This study was aimed at investigating the effect of crude oil contaminated feeds on selected serum enzymes and electrolyte levels in Albino wistar rats. Albino wistar rats weighing between 180g to 200g were obtained from Ladoke Akintola University of Technology Ogbomosho, OyoState and used for the study. The animals were grouped into five study groups with six (6) animals in each group. The animals were kept in a wellventilated room comprising control group, crude oil group, garlic treated group, Vitamin C treated group and Vitamin E treated group. | Assessment of selected hepatic serum enzymes in contaminated crude-oil feeds on albino wistar rats 2018 7 8 280-290 International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 7 Number 08 2018 Journal homepage http Original Research Article https Assessment of Selected Hepatic Serum Enzymes in Contaminated Crude-Oil Feeds on Albino Wistar Rats . Ukpanukpong1 . Basiru1 . Obadare2 and . Omang1 1 Department of Biochemistry Faculty of Basic Medical Sciences University of Calabar Nigeria 2 Department of Biochemistry College of Natural Sciences Joseph Ayo Babalola University Ikeji -Arakeji Osun State Nigeria Corresponding author ABSTRACT This study was aimed at investigating the effect of crude oil contaminated feeds on selected serum enzymes and electrolyte levels in Albino wistar rats. Albino wistar rats weighing between 180g to 200g were obtained from Ladoke Akintola University of Keywords Technology Ogbomosho OyoState and used for the study. The animals were grouped into five study groups with six 6 animals in each group. The animals were kept in a well- Body weight ventilated room comprising control group crude oil group garlic treated group Vitamin C Serum enzymes treated group and Vitamin E treated group. The animals were fed with contaminated feeds Electrolyte level 25mg of the antioxidant specified for each group simultaneously for two weeks. However control group were only fed with the normal while the crude oil group was not treated with Article Info the antioxidant. The levels of LDH and GGT concentrations increased significantly Accepted P gt in crude oil only fed group but LDH showed low concentration on treatment with 04 July 2018 vitamin E in the activities of AST ALT ALP in groups fed with crude oil contaminated diet when compared to the control and these sharp changes were ameliorated after 28 days of antioxidant treated

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