TAILIEUCHUNG - EPIPAGE 2: A preterm birth cohort in France in 2011

Children born at low gestational ages face a range of risks and number of neonates surviving very preterm birth is increasing. We present the objectives and methods of a French national cohort of very and moderately preterm children, the EPIPAGE 2 study. | Ancel et al. BMC Pediatrics 2014 14 97 http 1471-2431 14 97 BMC Pediatrics STUDY PROTOCOL Open Access EPIPAGE 2 a preterm birth cohort in France in 2011 Pierre-Yves Ancel1 2 3 Francois Goffinet1 2 4 and EPIPAGE 2 Writing Group Abstract Background Children born at low gestational ages face a range of risks and number of neonates surviving very preterm birth is increasing. We present the objectives and methods of a French national cohort of very and moderately preterm children the EPIPAGE 2 study. It aims to examine short- and long-term outcomes of very preterm children and their determinants. Methods Design Eligible participants for this prospective population-based study include all infants live born or stillborn and all terminations of pregnancy between 22 and 31 completed weeks of gestation in all the maternity units in 25 French regions. In addition a sample of moderate preterm births . births and late terminations at 32-34 weeks was included in the same regions. In all 7804 babies stillbirths and live births and terminations of pregnancy out of 8400 eligible births in France in 2011 that were either very 22-31 weeks or moderately preterm 32-34 weeks were included. Data on pregnancy delivery and neonatal events were extracted from the obstetric and neonatal records. The follow-up will collect information at corrected ages of one and 2 years and at 5 8 and 12 years of age. Of the 4467 children discharged alive from the hospital and eligible for follow-up 155 4 families refused further follow-up and 22 died before one-year of age. Finally 4290 were included in the follow-up. Eight additional projects investigating specific hypotheses among subsamples of the cohort by collecting specific data in addition to the core cohort data are being conducted to investigate 1 diagnosis of histologic chorioamnionitis 2 early biomarkers of child health 3 attitudes of care for extremely preterm infants 4 painful procedures in neonatal intensive care units

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