TAILIEUCHUNG - Antibacterial activity of silver nanoparticles

Bacterial infections are a major cause of chronic infections and mortality. Drug resistant microorganisms pose a serious public health problem and strategies for controlling bacterial activity are needed. Nanoparticles have emerged as a novel alternative to overcome bacterial multidrug resistance due to misuse and abuse of antibiotics. Their use as antimicrobial agents could overcome mechanisms of bacterial resistance as the microbicidal nature of nanoparticles result from direct contact with the bacterial cell wall, inhibiting cellular adhesion and attachment, without the need to penetrate into the cell, interfering in bacterial physiology, quorum sensing, and avoiding biofilm development. The physicochemical properties of nanoparticles are significant elements that regulate their antibacterial actions. Moreover, environmental conditions, the bacterial strain, and the exposure time are other major factors that influence their effects. This review focuses on the antibacterial mechanism and effect of silver nanoparticles, as well as the potential use as an alternative antimicrobial agent. | EXCELLENT PUBLISHERS International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 8 Number 08 2019 Journal homepage http Original Research Article https Antibacterial Activity of Silver Nanoparticles Gihan A. EL Batouti Department of Microbiology and Immunology Faculty of Pharmacy Pharos University in Alexandria Egypt Corresponding author ABSTRACT Keywords Antibacterial activity Antibiotics Silver nanoparticles Article Info Accepted 10 July 2019 Available Online 10 August 2019 Bacterial infections are a major cause of chronic infections and mortality. Drug resistant microorganisms pose a serious public health problem and strategies for controlling bacterial activity are needed. Nanoparticles have emerged as a novel alternative to overcome bacterial multidrug resistance due to misuse and abuse of antibiotics. Their use as antimicrobial agents could overcome mechanisms of bacterial resistance as the microbicidal nature of nanoparticles result from direct contact with the bacterial cell wall inhibiting cellular adhesion and attachment without the need to penetrate into the cell interfering in bacterial physiology quorum sensing and avoiding biofilm development. The physicochemical properties of nanoparticles are significant elements that regulate their antibacterial actions. Moreover environmental conditions the bacterial strain and the exposure time are other major factors that influence their effects. This review focuses on the antibacterial mechanism and effect of silver nanoparticles as well as the potential use as an alternative antimicrobial agent. Introduction The properties of metal nanoparticles NPs have been widely studied for their antimicrobial activity. The most tested metallic NP s are silver copper gold aluminum titanium iron and zinc Seil et al. 2012 Aderibigbe 2017 . They have shown broad spectrum antimicrobial activity against Gram positive and negative bacteria .

• Hoá học
• Antibacterial activity
• Silver nanoparticles
• Antibacterial activity of silver nanoparticles
• Antimicrobial agents could overcome mechanisms
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• Evaluation of antibacterial activity
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• Co culture method
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