TAILIEUCHUNG - Role and new insights of pirfenidone in fibrotic diseases

Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-β1, TNF-α, PDGF and COL1A1 expression, which is highly related to prevent or remove excessive deposition of scar tissue in several organs. | Int. J. Med. Sci. 2015 Vol. 12 840 IVYSPRING ĩtttonmtìnníií n-C OM ơrdrnf ĩriữnrữc INTERNATIONAL PUBLISHER international journal Oj jVLeaicai Sciences 2015 12 11 840-847. doi Review Role and New Insights of Pirfenidone in Fibrotic Diseases David Alejandro Lopez-de la Mora1 Cibeles Sanchez-Roque1 Margarita Montoya-Buelna1 Sergio Sanchez-Enriquez1 Silvia Lucano-Landeros1 Jose Macias-Barragan1 2 Juan Armendariz-Borunda1 E 1. Institute for Molecular Biology and Gene Therapy Department of Molecular Biology and Genomics University of Guadalajara Sierra Mojada St. 950 Guadalajara 44280 Mexico. 2. Departamento de Ciencias de la Salud CUValles University of Guadalajara Guadalajara - Ameca km. Ameca 46600 Mexico. El Corresponding author armdbo@ 2015 Ivyspring International Publisher. Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. See http terms for terms and conditions. Received Accepted Published Abstract Pirfenidone PFD is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-p1 TNF-a PDGF and COL1A1 expression which is highly related to prevent or remove excessive deposition of scar tissue in several organs. Basic and clinical evidence suggests that PFD may safely slow or inhibit the progressive fibrosis swelling after tissue injuries. Furthermore a number of evidence suggests that this molecule will have positive effects in the treatment of other inflammatory diseases. This review contains current research in which PFD has been used as the treatment of several diseases and focus mainly in the outcomes related to improve inflammation and fibrogenesis. Therefore the main goal of this review is to focus on the novel findings of PFD efficacy rather than deepen in the chemical aspects of the molecule. Key words Pirfenidone fibrosis inflammation .

• Y khoa - Dược
• BMC Pediatrics
• Idiopathic pulmonary fibrosis
• Non peptide synthetic molecule
• TNF α
• COL1A1 expression
• Acute otitis media
• Primary care pediatrics
• Pneumatic otoscope
• Educational programmes concerning
• National Institutes of Health
• Pediatric integrative medicine
• Healthcare professionals
• Alternative medicine
• Lumbar puncture
• Early onset neonatal sepsis
• American Academy of Pediatrics
• Group B Streptococcus
• 9 Kids’ Inpatient Database
• Public health
• Tasmanian Law Reform Institute
• Non therapeutic circumcision
• Long QT syndrome
• Standing test
• Pediatric emergency department
• Ventricular arrhythmias
• Acute respiratory infection
• Under five years
• Death especially
• Binary logistic regression analysis
• Pediatrics mortality
• Emergency department
• Tikur Anbessa Specialized Tertiary Hosptal
• Neonatal intensive care unit
• RV infection
• Pediatrics guidelines criteria
• Gynecology hospitals
• Demographic data collection
• Electronic health record
• Health care organizations
• Screen viewing
• Psychological wellbeing
• Moderate to vigorous intensity physical activity
• Child abuse pediatrics
• Social risk indicators
• Non social cues
• CAP risk perception
• Not included in the title
• Quality of health care
• Patient satisfaction
• Emergency medical services
• Isolated unilateral temporalis muscle hypertrophy
• IUTMH in pediatrics
• Masticatory muscle hypertrophies
• Visual disturbances
• Pediatrics antiretroviral market
• Pediatric antiretroviral prices
• Global Price Reporting Mechanism
• Price trends
• Pediatric antiretroviral procurement
• Hospitalized children
• Antimicrobial stewardship
• Prescribing antimicrobials
• Discontinuing empiric antimicrobials
• Pediatric tumors
• Infantile orbital tumors
• Isolated enophthalmos
• Orbital tumors
• Care seeking behavior
• Traditional medicine
• National Hospital of Pediatrics
• Neonatal jaundice
• Transcutaneous bilirubin
• Neonatal hyperbilirubinemia
• Especially kernicterus
• Parental decisions regarding immunization
• Knowledge practices
• Immunization rate
• Knowledge practice
• Factors underlying inadequate
• Unvaccinated children
• Epileptic attack
• School absenteeism
• Childhood epilepsy
• Epilepsy in Ethiopia
• Social media
• Infant care
• Anticipatory guidance
• Preschool teachers
• Knowledge retention
• Pediatric first aid
• Ulcerative colitis
• Inflammatory bowel diseases
• Childhood onset Crohn’s disease
• Histopathological examination
• Intestinal spirochetosis
• Brachyspira aalborgi
• Brachyspira pilosicoli
• Inflammatory bowel disease