TAILIEUCHUNG - Optimization of nutrients and process parameters for improved production of bioactive metabolite Butyrolactone i by Aspergillus terreus strains under submerged fermentation

Aspergilli, a large and diverse genus of ubiquitous filamentous fungi are the source of diverse secondary metabolites that can be used in the development of medications to treat diseases. Butyrolactone I is produced as a secondary metabolite by A. terreus. Butyrolactone I is a potent inhibitor of the eukaryotic cyclin-dependent kinases (CDK’s), protein kinases which control cell progression in all eukaryotes. Cyclin-dependent kinases are involved in numerous diseases in human beings like, cancer, stroke, diabetes, inflammation and AIDS. Butyrolactone I can become a life saving molecule in the above said diseases. In the present investigation the concentrations of carbon, nitrogen and phosphate sources and different fermentation conditions like temperature, media pH, agitation and incubation period were screened for their effect on the production of Butyrolactone I by two strains of A. terreus. The optimum nutrient concentrations and fermentation conditions for maximum production of Butyrolactone I were identified. | Optimization of nutrients and process parameters for improved production of bioactive metabolite Butyrolactone i by Aspergillus terreus strains under submerged fermentation

• Sinh học
• Aspergillus terreus
• Butyrolactone I
• Nutrient concentrations
• Fermentation conditions
• Aspergillus terreus strains
• Chủng Aspergillus terreus Đ1
• Chất kháng sinh
• Tối ưu điều kiện nuôi cấy
• Chủng nấm sợi phân lập
• Chủng nấm sợi Đ1
• Hoạt tính kháng sinh
• Cold active
• Cold temperature fermentation
• Carboxymethyl cellulases
• Cold active enzymes
• Cold active endoglucanase
• Optimization of physical
• Nutritional factors
• Enhanced production of lignocellulolytic enzymes
• Submerged conditions
• Aspergillus terreus FJAT 31011
• BMC Biotechnology
• α L Rhamnosidase
• Enzymatic conversion
• Amino acid
• Công nghệ nhiệt đới
• Sinh tổng hợp lovastatin
• Chủng vi nấm
• Môi trường nuôi cấy MEA
• Enzyme chống ung thư
• Sản xuất enzyme L sparaginase
• Nấm Aspergillus terreus SF 981
• Phương pháp lên men bán rắn
• Sản xuất enzyme ngoại bào
• BMC Pharmacology and Toxicology
• Case report
• Invasive aspergillosis
• Therapeutic drug monitoring
• Fusarium solani
• Alternaria solani
• Spicaria spp
• Aspergillus fumigatus
• Aspergillus flavus
• Khả năng ức chế sinh trưởng
• Rừng ngập mặn
• Chủng nấm sợi
• Phân loại chủng nấm sợi
• Tuyển chọn chủng nấm sợi