TAILIEUCHUNG - Anti-ds DNA levels and C3 and C4 complement levels in suspected flare up of systemic lupus erythematosus patients attending a Tertiary care Hospital

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with a variable clinical course and a wide range of organ manifestations. 101 Blood samples were tested for both anti-dsDNA and Complement levels in patients satisfying the 1982 American College of Rheumatology (ACR) criteria (updated in 1997) for SLE with suspected clinical flares using Euroimmun ELISA Anti-ds DNA-NcX ELISA (IgG) kit and by Nephelometry using the Nephstar kit for both the complements C3 and C4. In majority of patients Anti ds DNA, C3 and C4 levels were normal and almost same number of patients had Anti ds DNA, C3 were increased with decreased C4 levels. The high index of clinical suspicion and concurrent laboratory estimation of Anti ds DNA, C3 and C4 levels will help the clinician in the diagnosis and initiation of proper treatment of SLE and its flare ups. | Anti-ds DNA levels and C3 and C4 complement levels in suspected flare up of systemic lupus erythematosus patients attending a Tertiary care Hospital

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