TAILIEUCHUNG - Triterpenoids from Phyllanthus acidus (L.) Skeels

Skeels growing in Binh Thuan province, six compounds phyllanthol (1), glochidone (2), lupeol (3), glochidonol (4), -lupene (5), and spruceanol (6) were isolated. Their structures were established by extensive spectroscopic analysis as well as comparison with c. This is the first time that compounds 4-6 were found in Phyllanthus acidus (L.) Skeels. | TẠP CHÍ PHÁT TRIỀN KHOA HỌC CÔNG NGHỆ CHUYÊN SAN KHOA HỌC Tự NHIÊN TẬP 2 SỐ 2 2018 71 Triterpenoids from Phyllanthus acidus L. Skeels Duong Thuc Huy1 Nguyen Huu Hung2 Nguyen Thi Anh Tuyet1 Bui Xuan Hao1 Abstract The genus Phyllanthus Phyllanthaceae includes more than 900 plant species found in tropical and subtropical regions. Many of these species are widely used in folk medicine. The leaves roots and stem bark of Phyllanthus acidus L. Skeels have been used in Vietnamese folk medicine as an antibacterial antiviral analgesic anti-inflammatory neuroprotective hepatoprotective antifibrotic. From the ethanol extract of the roots of Phyllanthus acidus L. Skeels growing in Binh Thuan province six compounds phyllanthol 1 glochidone 2 lupeol 3 glochidonol 4 a-lupene 5 and spruceanol 6 were isolated. Their structures were established by extensive spectroscopic analysis as well as comparison with NMR data in the literatures. This is the first time that compounds 4-6 were found in Phyllanthus acidus L. Skeels. Keywords Phyllanthus acidus L. Skeels lupane phyllanthol triterpene 1 INTRODUCTION Previous studies on chemical constituents of Phyllanthus acidus L. Skeels resulted in the discovery of various natural products such as triterpenes phytosterols phenolic compounds and norbisabolane-type sesquiterpenes 1-3 . Among them norbisabolane serquiterpenoids displayed strong anti-viral hepatitis B effect 3 . Our previous study on the stem bark of Phyllanthus acidus L. Skeels led to the isolation of three compounds 4 . This paper reports details of the isolation of six compounds from the roots of Phyllanthus acidus L. Skeels including phyllanthol 1 glochidone Received 15-8-2017 Accepted 12-9-2017 Published 30-8-2018 Duong Thuc Huy Nguyen Thi Anh Tuyet Bui Xuan Hao Ho Chi Minh City University of Pedagogy. Nguyen Huu Hung - Nguyen Tat Thanh University Email buixuanhaodhsp@ 2 lupeol 3 glochidonol 4 a-lupene A 5 and spruceanol 6 . Their structure were elucidated on the basis .

• Hoá học
• Triterpenoids from Phyllanthus acidus (L
• ) Skeels
• The genus Phyllanthus
• Extensive spectroscopic analysis
• Comparison with NMR data
• Comparison with NMR data
• Chemical constituents of the lichen Roccella sinensis growing
• The lichen Roccella sinensis growing in Binh Thuan province
• Thin layer chro matography
• Thin layer chromatography
• Normal phase silica gel column chromatography
• Vietnam Journal of Science and Technology
• Flavonoids from the leaves of aralia hiepiana
• The leaves of aralia hiepiana
• The literature data
• NMR techniques and by comparison