TAILIEUCHUNG - Oral cleft prevention program (OCPP)

Oral clefts are one of the most common birth defects with significant medical, psychosocial, and economic ramifications. Oral clefts have a complex etiology with genetic and environmental risk factors. | Wehby et al. BMC Pediatrics 2012 12 184 http 1471-2431 12 184 BMC Pediatrics STUDY PROTOCOL Open Access Oral cleft prevention program OCPP I -A I A Ỉ J Ia Ia f1 t I A r ZAA A VA ZA 7 FA A VA I I V A ỉ ZA r A t I LArrAÌrA2 I A VAA I A C A I ỈX 4 ỉ va4 za VA I V o I r Ia I A fl Ĩ AftA3 c DnAlAí AỈ5 George L vvehby Norman Goco uanilo Moretti-Ferreira lemis Felix Antonio Richieri-Costa Carla Paoovani c IAIZAi A VAA I I I A ì I A l I ZAV z A I I rA A r A A A5 D I I I D A r A I r A 6 c T A Ỉ r I it At Az-7 7 I z I A r I_I A r4 t A Z A I I 7 Fernanda Queiros Camilla Vila Nova Guimaraes Rui Pereira Steve Litavecz lyier Hartwell Hrishikesh Chakraborty7 Lorette Javois8 and Jeffrey C Murray1 Abstract Background Oral clefts are one of the most common birth defects with significant medical psychosocial and economic ramifications. Oral clefts have a complex etiology with genetic and environmental risk factors. There are suggestive results for decreased risks ofcleft occurrence and recurrence with folic acid supplements taken at preconception and during pregnancy with a stronger evidence for higher than lower doses in preventing recurrence. Yet previous studies have suffered from considerable design limitations particularly non-randomization into treatment. There is also well-documented effectiveness for folic acid in preventing neural tube defect occurrence at mg and recurrence with 4 mg. Given the substantial burden of clefting on the individual and the family and the supportive data for the effectiveness of folic acid supplementation as well as its low cost a randomized clinical trial of the effectiveness of high versus low dose folic acid for prevention ofcleft recurrence is warranted. Methods design This study will assess the effect of 4 mg and mg doses of folic acid taken on a daily basis during preconception and up to 3 months of pregnancy by women who are at risk of having a child with nonsyndromic cleft lip with without palate NSCL P on the

• Y khoa - Dược
• BMC Pediatrics
• Oral clefts
• Cleft lip
• Cleft palate
• Craniofacial anomalies
• Congenital anomalies
• Birth defects
• Folic acid
• Acute otitis media
• Primary care pediatrics
• Pneumatic otoscope
• Educational programmes concerning
• National Institutes of Health
• Pediatric integrative medicine
• Healthcare professionals
• Alternative medicine
• Lumbar puncture
• Early onset neonatal sepsis
• American Academy of Pediatrics
• Group B Streptococcus
• 9 Kids’ Inpatient Database
• Public health
• Tasmanian Law Reform Institute
• Non therapeutic circumcision
• Long QT syndrome
• Standing test
• Pediatric emergency department
• Ventricular arrhythmias
• Acute respiratory infection
• Under five years
• Death especially
• Binary logistic regression analysis
• Pediatrics mortality
• Emergency department
• Tikur Anbessa Specialized Tertiary Hosptal
• Neonatal intensive care unit
• RV infection
• Pediatrics guidelines criteria
• Gynecology hospitals
• Demographic data collection
• Electronic health record
• Health care organizations
• Screen viewing
• Psychological wellbeing
• Moderate to vigorous intensity physical activity
• Child abuse pediatrics
• Social risk indicators
• Non social cues
• CAP risk perception
• Not included in the title
• Quality of health care
• Patient satisfaction
• Emergency medical services
• Isolated unilateral temporalis muscle hypertrophy
• IUTMH in pediatrics
• Masticatory muscle hypertrophies
• Visual disturbances
• Pediatrics antiretroviral market
• Pediatric antiretroviral prices
• Global Price Reporting Mechanism
• Price trends
• Pediatric antiretroviral procurement
• Hospitalized children
• Antimicrobial stewardship
• Prescribing antimicrobials
• Discontinuing empiric antimicrobials
• Pediatric tumors
• Infantile orbital tumors
• Isolated enophthalmos
• Orbital tumors
• Care seeking behavior
• Traditional medicine
• National Hospital of Pediatrics
• Neonatal jaundice
• Transcutaneous bilirubin
• Neonatal hyperbilirubinemia
• Especially kernicterus
• Parental decisions regarding immunization
• Knowledge practices
• Immunization rate
• Knowledge practice
• Factors underlying inadequate
• Unvaccinated children
• Epileptic attack
• School absenteeism
• Childhood epilepsy
• Epilepsy in Ethiopia
• Social media
• Infant care
• Anticipatory guidance
• Preschool teachers
• Knowledge retention
• Pediatric first aid
• Ulcerative colitis
• Inflammatory bowel diseases
• Childhood onset Crohn’s disease
• Histopathological examination
• Intestinal spirochetosis
• Brachyspira aalborgi
• Brachyspira pilosicoli
• Inflammatory bowel disease