TAILIEUCHUNG - In vitro transdermal permeation of fenoterol hydrobromide

The aim of this study was to determine if transdermal penetration of fenoterol, a b-agonist drug, could be enhanced and controlled by formulation modification and formulation of transdermal patches. Pre-formulation studies were performed to determine the feasibility of a transdermal dosage form of fenoterol. Penetration of fenoterol was determined using the hairless guinea pig skin with unjacketed Franz diffusion cell. Transdermal patches were formulated using drug in-adhesive technique. Several enhancers were investigated for fenoterol skin penetration. Transcutol–oleic acid co-solvent gives the highest drug flux among all tested liquid formulations. Pretreatment of the skin with oleic acid 2 h before patch application significantly increases drug diffusion. Cis-oleic acid gives best results compared to oleic acid. Azone derivative (1-dodecyl-2-pyrrolidinone) gives the highest drug diffusion amongst all tested enhancers. Results of this study show the feasibility of using fenoterol formulated in transdermal delivery system in the treatment of chronic asthma to improve patient compliance, bioavailability and reduce the inter-subject variability. | Journal of Advanced Research 2012 3 125-132 Cairo University Journal of Advanced Research ORIGINAL ARTICLE In vitro transdermal permeation of fenoterol hydrobromide Ahmed H. Elshafeey a b Yassin E. Hamza b Soad Y. Amin b Hossein Zia a a Applied Pharmaceutical Sciences College of Pharmacy University of Rhode Island Kingston RI 02881 USA b Pharmaceutics Department College of Pharmacy Cairo University Egypt Received 28 March 2011 revised 25 May 2011 accepted 25 May 2011 Available online 12 July 2011 KEYWORDS Fenoterol Transdermal Patches Enhancers Duro-Tak Abstract The aim of this study was to determine if transdermal penetration of fenoterol a P-agonist drug could be enhanced and controlled by formulation modification and formulation of transder-mal patches. Pre-formulation studies were performed to determine the feasibility of a transdermal dosage form of fenoterol. Penetration of fenoterol was determined using the hairless guinea pig skin with unjacketed Franz diffusion cell. Transdermal patches were formulated using drug in-adhesive technique. Several enhancers were investigated for fenoterol skin penetration. Transcutol-oleic acid co-solvent gives the highest drug flux among all tested liquid formulations. Pretreatment of the skin with oleic acid 2 h before patch application significantly increases drug diffusion. Cis-oleic acid gives best results compared to oleic acid. Azone derivative 1-dodecyl-2-pyrrolidinone gives the highest drug diffusion amongst all tested enhancers. Results of this study show the feasibility of using fen-oterol formulated in transdermal delivery system in the treatment of chronic asthma to improve patient compliance bioavailability and reduce the inter-subject variability. 2011 Cairo University. Production and hosting by Elsevier . All rights reserved. Introduction The transdermal route of administration has been recognized as one of the highly potential routes. It has the advantages Corresponding author. Tel. 20 105840261 fax 20 2 .

• Sinh học
• In vitro transdermal permeation
• Fenoterol hydrobromide
• Inter subject variability
• Transdermal delivery system
• Transcutol–oleic acid
• BMC Pharmacology and Toxicology
• Transdermal drug delivery
• Non steroidal anti inflammatory drug
• In vitro permeation study
• Physical penetration enhancement