TAILIEUCHUNG - Therapeutic potential of endothelial progenitor cells in a rat model of epilepsy: Role of autophagy

Epilepsy is one of the most well-known neurological conditions worldwide. One-third of adult epileptic patients do not respond to antiepileptic drugs or surgical treatment and therefore suffer from the resistant type of epilepsy. Stem cells have been given substantial consideration in the field of epilepsy therapeutics. The implication of pathologic vascular response in sustained seizures and the eminent role of endothelial progenitor cells (EPCs) in maintaining vascular integrity tempted us to investigate the potential therapeutic effects of EPCs in a pentylenetetrazole (PTZ)-induced rat model of epilepsy. Modulation of autophagy, a process that enables neurons to maintain an equilibrium of synthesis, degradation and subsequent reprocessing of cellular components, has been targeted. Intravenously administered EPCs homed into the hippocampus and amended the deficits in memory and locomotor activity. The cells mitigated neurological damage and the associated histopathological alterations and boosted the expression of brain-derived neurotrophic factor. EPCs corrected the perturbations in neurotransmitter activity and enhanced the expression of the downregulated autophagy proteins light chain protein-3 (LC-3), beclin1, and autophagy-related gene-7 (ATG-7). | Therapeutic potential of endothelial progenitor cells in a rat model of epilepsy: Role of autophagy

• Y khoa - Dược
• Endothelial progenitor cells
• Neuronal damage
• Therapeutic potential
• Rat model of epilepsy
• Role of autophagy
• Circulating endothelial progenitor cells
• Mononuclear cells
• Atherosclerotic plaque
• Circulating EPCs
• BMC Cancer
• Circulating endothelial cells
• Breast cancer
• Dynamically during
• BMC Pulmonary Medicine
• Progenitor cells
• Endothelial cells
• Flow cytometry
• Significantly higher percentage
• Multi organ disease
• Micro carrier
• Cell therapy
• Antibody against human CD34
• Bioreactor micro carrier cell culture system
• BMC Pediatrics
• Congenital heart disease
• pulmonary arterial hypertension
• Atrial aeptal defect
• Human EPCs
• Acute myocardial infarction
• Regenerate infracted myocardium
• Neovascularisation development
• Human umbilical vein endothelial cells
• Gene expression
• Octamer binding transcription factor 4
• Circulating endothelial cell
• BMC Musculoskeletal Disorders
• Stem cells
• Juvenile Idiopathic Arthritis
• Promote angiogenesis
• Rheumatoid arthritis
• After school exercise programme
• Carotid intima media thickness
• Endothelial cell function
• Obese children
• Vascular endothelial
• Transmembrane protein
• Inhibiting angiogenesis
• Mouse embryos
• BMC Anesthesiology
• Hypoxia inducible factor 1α
• Stromal cell derived factor 1α
• Hematopoietic stem cells
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• trình bày báo cáo
• tài liệu báo cáo khoa học
• nghiên cứu y học
• báo cáo y học
• kiến thức y học
• báo cáo khoa học
• công trình nghiên cứu về y học
• tài liệu về y học
• Porcine pericardium
• Sodium dodecyl sulfate
• DNA quantification
• Mechanical properties
• Systemic sclerosis
• Cellular regeneration
• Mesenchymal transdifferentiation
• Severe microvasculopathy
• BMC Molecular and Cell Biology
• Retinal neovascularization
• Gene therapy
• Endostatin transfected EPCs
• Tissue engineering
• Bone marrow
• Functional angiogenic capacity
• Bioartificial tissues