TAILIEUCHUNG - Human Schistosomiasis: Clinical Perspective: Review

The clinical manifestations of schistosomiasis pass by acute, sub acute and chronic stages that mirror the immune response to infection. The later includes in succession innate, TH1 and TH2 adaptive stages, with an ultimate establishment of concomitant immunity. Some patients may also develop late complications, or suffer the sequelae of co-infection with other parasites, bacteria or viruses. Acute manifestations are species-independent; occur during the early stages of invasion and migration, where infection-naivety and the host’s racial and genetic setting play a major role. Sub acute manifestations occur after maturity of the parasite and settlement in target organs. They are related to the formation of granulomata around eggs or dead worms, primarily in the lower urinary tract with Schistosoma haematobium, and the colon and rectum with Schistosoma mansoni, Schistosoma japonicum, Schistosoma intercalatum and Schistosoma mekongi infection. Secondary manifestations during this stage may occur in the kidneys, liver, lungs or other ectopic sites. Chronic morbidity is attributed to the healing of granulomata by fibrosis and calcification at the sites of oval entrapment, deposition of schistosomal antigen-antibody complexes in the renal glomeruli or the development of secondary amyloidosis. | Journal of Advanced Research 2013 4 433-444 Cairo University Journal of Advanced Research REVIEW Human Schistosomiasis Clinical Perspective Review Rashad S. Barsoum a Gamal Esmat b Tamer El-Baz b a Department of Internal Medicine Cairo University Egypt b Department of Tropical Medicine Cairo University Egypt Received 16 June 2012 revised 21 January 2013 accepted 24 January 2013 Available online 3 April 2013 KEYWORDS Hepatointestinal schistosomiasis Urinary schistosomiasis Neuroschistosomiasis Schistosomal coinfection Treatment schistosomiasis Abstract The clinical manifestations of schistosomiasis pass by acute sub acute and chronic stages that mirror the immune response to infection. The later includes in succession innate TH1 and TH2 adaptive stages with an ultimate establishment of concomitant immunity. Some patients may also develop late complications or suffer the sequelae of co-infection with other parasites bacteria or viruses. Acute manifestations are species-independent occur during the early stages of invasion and migration where infection-naivety and the host s racial and genetic setting play a major role. Sub acute manifestations occur after maturity of the parasite and settlement in target organs. They are related to the formation of granulomata around eggs or dead worms primarily in the lower urinary tract with Schistosoma haematobium and the colon and rectum with Schistosoma mansoni Schistosoma japonicum Schistosoma intercalatum and Schistosoma mekongi infection. Secondary manifestations during this stage may occur in the kidneys liver lungs or other ectopic sites. Chronic morbidity is attributed to the healing of granulomata by fibrosis and calcification at the sites of oval entrapment deposition of schistosomal antigen-antibody complexes in the renal glomeruli or the development of secondary amyloidosis. Malignancy may complicate the chronic lesions in the urinary bladder or colon. Co-infection with salmonella or hepatitis viruses B or C may .

• Y khoa - Dược
• Hepatointestinal schistosomiasis
• Urinary schistosomiasis
• Schistosomal coinfection
• Treatment schistosomiasis
• Secondary amyloidosis
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