TAILIEUCHUNG - Dexamethasone abrogates the antimicrobial and antibiofilm activities of different drugs against clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa

Staphylococcus aureus and Pseudomonas aeruginosa are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding sequelae. Although different pharmaceutical dosage forms of antimicrobials combined to corticosteroids are available, studies on the interference of corticosteroids on the pharmacological activity of antimicrobials are scarce and controversial. Here, we provide evidence of the interference of dexamethasone on the pharmacological activity of clinically important antimicrobial drugs against biofilms and planktonic cells of S. aureus and P. aeruginosa. Broth microdilution assays of minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum biofilm eradication concentration (MBEC) of gentamicin, chloramphenicol, oxacillin, ceftriaxone and meropenem were conducted with and without the addition of dexamethasone. The effect of all drugs was abrogated by dexamethasone in their MIC, MBC, and MBEC, except gentamicin and meropenem, for which the MBC was not affected in some strains. The present study opens doors for more investigations on in vitro and in vivo effects and safety of the combination of antimicrobials and glucocorticoids. | Dexamethasone abrogates the antimicrobial and antibiofilm activities of different drugs against clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa

• Y khoa - Dược
• Dexamethasone abrogates
• Antibiofilm activities
• Different drugs against clinical isolates
• Staphylococcus aureus
• Pseudomonas aeruginosa
• trình bày báo cáo
• tài liệu báo cáo khoa học
• báo cáo y học
• kiến thức y học
• nghiên cứu y học
• Đồ án tốt nghiệp đại học
• Công nghệ sinh học
• Độ nhiễm khuẩn của Pseudomonas aeruginosa
• Khả năng kháng kháng sinh của Pseudomonas aeruginosa
• Nhiễm khuẩn nước uống
• Định lượng Pseudomonas aeruginosa trong nước uống
• Kháng kháng sinh
• Vi khuẩn từ bệnh phẩm
• Chủng P
• aeruginosa
• Bệnh nhân nhiễm Pseudomonas aeruginosa
• Sản xuất Carbapenemase
• Metallo beta lactamase
• Producing pseudomonas Aeruginosa isolates
• Aeruginosa isolates
• Multidrug resistance
• Pseudomonas aeruginosa (P aeruginosa)
• Antimicrobial resistance pattern
• Various clinical samples
• Government medical college
• Đề kháng kháng sinh Staphylococci
• Đề kháng kháng sinh Pseudomonas aeruginosa
• Viêm loét giác mạc
• Bệnh viện mắt thành phố Hồ Chí Minh
• Đề kháng kháng sinh thông dụng
• Antimicrobial sensitivity testing
• Drug resistance
• Medical tips
• Blood from patients
• Pseudomonas aeruginosa recovered
• LasA protease
• LasB protease
• Biotechnological potential
• Non pathogenic environmental isolate
• Pseudomonas aeruginosa MCCB 123
• Extracellular polysaccharides
• Larvicidal activity
• Pseudomonas aeruginosa B01
• Isolation and characterization
• Larvicidal extracellular polysaccharide
• Clinical isolates
• OprD protein profile
• Pseudomonas Aeruginosa isolates resistant
• Imipenem from patients
• Sludge using Pseudomonas Aeruginosa
• Environmental maintenance
• Industrial waste management
• Heavy metal like LEAD
• Celosia Cristata L
• Celosia cristata
• Pseudomonas Aeruginosa MCC 3198
• Potential for growth promotion
• Medicinal plant Celosia Cristata L
• Degradation of discarded
• Engine oil by Pseudomonas aeruginosa DP 1
• Used engine oil
• Oil degrading organisms
• Combined disc test
• MBL producing Pseudomonas aeruginosa
• Prevalence of ESBL
• Tertiary care hospital
• Nanosilver and antibiotics
• Antibiotics separately
• Pseudomonas aeruginosa clinical isolates
• Silver nano particles may provide safe
• Carbapenem resistance
• MBL genes
• Characterization of VIM
• IMP Metallobetalactamases
• Pseudomonas aeruginosa isolated
• Various clinical specimens
• Antibiotic resistance
• Pseudomonas aeruginosa strains isolated
• Skin host defences are destroyed
• Antibacterial activity
• Broccoli extracts
• Against Pseudomonas aeruginosa
• Antibacterial potential
• Kaempheria galangal
• Anti biofilm
• Anti plasmid pseudomonas aeruginosa
• Anti plasmid activites
• OprD Deficient Mutant
• Pseudomonas aeruginosa carbapenemase
• New phenotypic method
• Screen for OprD deficient mutant strains
• Extended spectrum beta lactamase
• Non extended spectrum beta lactamase
• Producing pseudomonas aeruginosa
• Occurrence of antimicrobial resistance
• Nosocomial infection
• Quantitative biofilm assay
• Pseudomonas aeruginosa isolates
• Clinical samples
• Arginine deaminase
• Fermentation parameters
• Bacterium pseudomonas aeruginosa PS2
• Arginine deaminase production
• Công nghệ hóa
• Khả năng hấp thu toluen
• Pseudomonas putida
• Hóa hữu cơ
• Ô nhiễm môi trường
• PCR based detection
• Mastitic cow milk
• Bovine Mastitis