TAILIEUCHUNG - HSDL2 promotes bladder cancer growth in vitro and in vivo

Bladder cancer is a common malignant urinary tumor, and patients with bladder cancer have poor prognosis. Abnormal lipid metabolism in peroxisomes is involved in tumor progression. Hydroxysteroid dehydrogenase-like 2 (HSDL2) localized in peroxisomes regulates fatty acid synthesis. | Int. J. Med. Sci. 2019 Vol. 16 654 IVYSPRING ĩvt ơ-rnrt irmrtí clrni t n lí ei-fCMo Tir lf Qriữvtrơc INTERNATIONAL PUBLISHER international journal Oj jVLeaicaiSciences 2019 16 5 654-659. doi Research Paper HSDL2 Promotes Bladder Cancer Growth In Vitro and In Vivo Ling-Hua Jia1 2 Mei-Di Hu3 Yuan Liu4 Xing Xiong2 Wei-Jia Wang5 Jin-Gen Wang2 Qiu-Gen Li6 1. Graduate Faculty Jiangxi Medical College Nanchang University Nanchang 330006 2. Department of Urology Jiangxi Provincial People s Hospital Affiliated to Nanchang University Nanchang 330006 3. Departments of Gerontology The First Affiliated Hospital of Nanchang University Nanchang 330006 4. Division of Nephrology The Fifth People s Hospital of Shanghai Fudan University Shanghai 200240 5. Department of Pathology The First Affiliated Hospital of Nanchang University Nanchang 330006 6. Department of Respiratory Medicine Jiangxi Provincial People s Hospital Affiliated to Nanchang University Nanchang 330006. El Corresponding author Dr. Qiu-Gen Li Department of Respiratory Medicine Jiangxi Provincial People s Hospital Affiliated to Nanchang University Nanchang 330006 . China. E-mail Drlqg66@ Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution CC BY-NC license https licenses by-nc . See http terms for full terms and conditions. Received Accepted Published Abstract Bladder cancer is a common malignant urinary tumor and patients with bladder cancer have poor prognosis. Abnormal lipid metabolism in peroxisomes is involved in tumor progression. Hydroxysteroid dehydrogenase-like 2 HSDL2 localized in peroxisomes regulates fatty acid synthesis. In the present study we reported that HSDL2 was upregulated in two human bladder cancer cell lines 5637 and T24 compared to normal human urothelial cells. Furthermore lentiviral-mediated HSDL2 knockdown inhibited the

• Y khoa - Dược
• Bladder cancer
• Cell proliferation
• Hydroxysteroid dehydrogenase like 2
• Abnormal lipid metabolism
• Normal human urothelial cells
• BMC Cancer
• Bladder calculus
• Chronic irritation
• Bladder outlet obstruction
• Bladder reconstruction
• Cancer worldwide
• Radical cystectomy
• Muscle invasive bladder cancer
• Urine markers
• Non muscle invasive bladder cancer
• Nuclear matrix protein 22
• Urinary bladder cancer antigen
• Clinical practice guidelines
• Transurethral resection of bladder tumour
• Urothelial carcinomas of bladder
• Immune infiltrates
• Human bladder cancer
• Bladder neoplasms
• Multiple imputation
• Mallorca Cancer Registry
• Genitourinary oncology
• Prostate cancer
• Upper tract tumors
• Advanced prostate cancer
• Invasive bladder cancer
• Bladder preservation strategies
• Upper tract cancer
• Squamous cell carcinoma
• Immune checkpoint inhibitors
• Bladder cancer therapy
• Pure squamous cell carcinoma
• DNA damage response
• O GlcNAcylation
• O linked β N acetylglucosamine transferase
• Quantitative PCR
• RNA binding proteins
• Nucleus cytoplasm co expression
• Treatment failure
• Metastatic bladder cancer
• Poor chemotherapeutic response
• Adjuvant chemotherapy
• Transitional cell carcinoma
• Human cancers
• Canine bladder cancer
• Cell lines
• Urinary exosomes
• Quality of life
• Promising biomarker
• B cell translocation gene
• Notch signalling
• Extracellular matrix
• Molecular mechanism
• Upper urinary tract urothelial cancer
• Double J stent
• Urine based assay
• DNA biomarkers
• Carcinoma in situ
• Toll like Receptor
• Increased endostatin protein
• Bladder cancer progress
• Cell growth and invasion
• Hippo signaling pathway
• Plays crucial role
• Adipocyte fatty acid binding protein
• Prognostic marker
• Non muscle invasive bladder cancers
• Overall survival
• ERH gene
• MYC gene
• Underlying mechanism
• Human bladder urothelial carcinoma
• Intravesical therapy
• Markov model
• Typical transurethral bladder resection
• Urinary bladder neoplasm
• Plasmacytoid variant
• Adjuvant cisplatin based chemotherapy
• Cox’s proportional hazards
• Urinary bladder neoplasms
• Propensity score matching
• Landmark analysis
• Journal of Biology
• Tumor microenvironment
• Mono macrophage
• CD163+/CD206+M2 mono macrophage
• Bladder cancer microenvironment