TAILIEUCHUNG - Increased susceptibility of post-weaning rats on high-fat diet to metabolic syndrome

The present study aimed to examine the effects of the types of high-calorie diets (high-fat and high-fathigh-sucrose diets) and two different developmental stages (post-weaning and young adult) on the induction of metabolic syndrome. Male, post-weaning and adult (3- and 8-week old, respectively) Sprague Dawley rats were given control, high-fat (60% kcal), and high-fat-high-sucrose (60% kcal fat + 30% sucrose water) diets for eight weeks (n = 6 to 7 per group). Physical, biochemical, and transcriptional changes as well as liver histology were noted. Post-weaning rats had higher weight gain, abdominal fat mass, fasting glucose, high density lipoprotein cholesterol, faster hypertension onset, but lower circulating advanced glycation end products compared to adult rats. This is accompanied by upregulation of peroxisome proliferator-activated receptor (PPAR) a and c in the liver and receptor for advanced glycation end products (RAGE) in the visceral adipose tissue. Post-weaning rats on high-fat diet manifested all phenotypes of metabolic syndrome and increased hepatic steatosis, which are linked to increased hepatic and adipocyte PPARc expression. | Increased susceptibility of post-weaning rats on high-fat diet to metabolic syndrome

• Y khoa - Dược
• Hepatic steatosis
• Peroxisome proliferator activated receptor
• Increased susceptibility
• Post weaning rats
• High fat diet to metabolic syndrome
• Metabolic syndrome
• Non alcoholic fatty liver disease
• Phosphodiesterase 3B
• Oxidative stress
• Insulin resistance
• Pro inflammatory cytokines
• Nonalcoholic fatty liver disease
• Vitamin D
• Common population
• Hepatitis C virus
• Interferon lambda 3
• Hepatocellular carcinoma
• Chronic hepatitis cirrhosis
• BMC Genomics
• Correlation network
• Transcriptional coordination
• Specific transcripts
• Steatosis free livers
• trình bày báo cáo
• tài liệu báo cáo khoa học
• tạp chí y học Medical Sciences
• báo cáo y học
• nghiên cứu y học
• RNA sequencing
• Differentially expressed genes
• Duck species
• RNAs extracted
• báo cáo khoa học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Dietary fructose
• Fatty acid oxidation
• Fatty acid β oxidation
• BMC Pediatrics
• Fatty liver
• Controlled attenuation parameter
• Proton density fat fraction
• Magnetic resonance spectroscopy
• Alanine aminotransferase