TAILIEUCHUNG - Advances in research on Rotavin-M1

“Rotavin-M1” is an oral live-attenuated vaccine that prevents diarrhea in children under five years old, produced from rotavirus strains G1P [1] on Vero cells. This vaccine has been studied for 16 years beginning with monitoring the local circulating strain and eventually establishing a seed lots system. The safety and immunogenicity of the vaccine were found equivalent to internationallyimported vaccines. | LIFE SCIENCES MEDICINE Advances in research on Rotavin-Ml Thi Luan Le1 Van Man Nguyen1 Thuy Huong Nguyen1 Duc Anh Dang2 Van Trang Nguyen2 Bich Hanh Tran1 Thi Giang Huong Tran3 Thi Oanh Tran3 Gia Khanh Pham4 Baoming Jiang5 Roger Glass6 Duncan Steel7 Dang Hien Nguyen1 1Center for the Research and Production of Vaccines and Biologicals National Institute of Hygiene and Epidemiology Ministry of Health Ministry of Science and Technology 5Center for Disease Control and Prevention CDC USA National Institute of Health NIH USA 7PATH USA Received 23 December 2016 accepted 24 February 2017 Abstract Rotavin-M1 is an oral live-attenuated vaccine that prevents diarrhea in children under five years old produced from rotavirus strains G1P 1 on Vero cells. This vaccine has been studied for 16 years beginning with monitoring the local circulating strain and eventually establishing a seed lots system. The safety and immunogenicity of the vaccine were found equivalent to internationally-imported vaccines. Keywords G1P Rotavin-Ml vaccine. Classification number Introduction The discovery of the rotavirus as one of the major causes of diarrhea in children has led to the expansion of research in order to develop vaccines to prevent or reduce the incidents and mortality from this disease. Epidemiological studies of diarrhea caused by rotavirus were particularly useful as prerequisites for research into a vaccine. Specific preventative measures in Vietnam support and protect general public health especially that of infants and young children. According to statistic data the annual incidence of diarrhea caused by rotavirus accounts for over 50 of children under age of five years old hospitalized in pediatric hospitals in Vietnam and about 5 300 - 6 800 deaths were reported annualy in children under five years old accounting for 8 to 11 of the mortality rate among children of the same age. Among about million of those born annualy it is estimated that 820 000 clinical visits 122 000

• Y khoa - Dược
• Advances in research on Rotavin M1
• Research on Rotavin M1
• Internationallyimported vaccines
• The vaccine were found equivalent
• The local circulating strain