TAILIEUCHUNG - Toxicological studies of Orthosiphon stamineus (Misai Kucing) standardized ethanol extract in combination with gemcitabine in athymic nude mice model

Pancreatic cancer has the highest mortality rate among cancers due to its aggressive biology and lack of effective treatment. Gemcitabine, the first line anticancer drug has reduced efficacy due to acquired resistance. The current study evaluates the toxicological effects of Orthosiphon stamineus () and its marker compound (rosmarinic acid) in combination with gemcitabine. (200 or 400 mg/kg/day) and rosmarinic acid (32 mg/kg/day) were administered orally and gemcitabine (10 mg/kg/3 days) intraperitoneally either alone or in combination treatment for fourteen days. Parameters including blood serum biochemistry, hematology, myeloid-erythroid ratio, incident of lethality, and histopathological analysis of liver, kidney, and spleen tissues were studied. Neither, individual drugs/extract nor chemo-herbal combinations at tested doses induced any toxicity and damage to organs in nude mice when compared to control group. Toxicological data obtained from this study will help to select the best doses of chemoherbal combination for future pancreatic xenograft tumor studies. | Toxicological studies of Orthosiphon stamineus (Misai Kucing) standardized ethanol extract in combination with gemcitabine in athymic nude mice model

• Y khoa - Dược
• Orthosiphon stamineus
• Rosmarinic acid
• Medicinal herb
• Pancreatic cancer
• Toxicological studies
• Vietnam Journal of Chemistry
• PTP1B inhibitory flavonols from Orthosiphon stamineus Benth
• PTP1B inhibitory flavonols
• Orthosiphon stamineus Benth
• Physicochemical data analyses
• Vietnam Journal of Science and Technology
• Methoxyflavones from orthosiphon stamineus
• PTP1B inhibitory activities
• Discovery of PTP1B inhibitors
• Mô sẹo bở
• Sự tạo dịch treo tế bào cây râu mèo
• Sự tạo dịch treo
• Tế bào cây râu mèo
• Sự nuôi cấy dịch treo tế bào
• Tạp chí Khoa học và Công nghệ
• Phương pháp nhân giống vô tính
• Phát triển nguồn gen cây râu mèo
• Nhân giống in vitro cây râu mèo
• Clonal progagation of Vietnamese
• Sinensetin using plant tissue culture technique
• Plant tissue culture technique
• Accession containing high content
• Luận án Tiến sĩ Hóa học
• Hóa hữu cơ
• Cây Râu mèo
• Hoạt tính sinh học
• Phổ khối va chạm electron
• Phổ hồng ngoại
• Dược liệu Râu mèo
• Phương pháp sắc kí lớp mỏng
• Phương pháp sắc ký lỏng hiệu năng cao
• Hợp chất hóa học của cây Râu mèo
• Acid ursolic
• Acid rosmarinic