TAILIEUCHUNG - Function of glia in aging and the brain diseases

Microglia cells during aging, neurodegeneration and neuroinflammation show different morphological and transcriptional profiles (related to axonal direction and cell adhesion). Furthermore, expressions of the receptors on the surface and actin formation compared to young are also different. | Int. J. Med. Sci. 2019 Vol. 16 1473 ivyspring international publisher Review InternationalJournal ofMedicalSciences 2019 16 11 1473-1479. doi Function of Glia in Aging and the Brain Diseases Soraya L. Valles1 Antonio Iradi1 Martin Aldasoro1 Jose M. Vila1 Constanza Aldasoro1 Jack de la Torre2 Juan Campos-Campos3 and Adrian Jorda1 3 1. Department of Physiology School of Medicine University of Valencia Spain. 2. University of Texas Austin Texas USA. 3. Department of Nursing Faculty of Nursing and Podiatry University of Valencia Spain. El Corresponding author Soraya Valles Department of Fisiologia Facultad de Medicina Av. Blasco Ibanez 15 Universidad de Valencia Valencia 46010 Spain Tel 34963983813 Fax 34963864642 E-mail . The author s . This is an open access article distributed under the terms of the Creative Commons Attribution License https licenses by . See http terms for full terms and conditions. Received Accepted Published Abstract Microglia cells during aging neurodegeneration and neuroinflammation show different morphological and transcriptional profiles related to axonal direction and cell adhesion . Furthermore expressions of the receptors on the surface and actin formation compared to young are also different. This review delves into the role of glia during aging and the development of the diseases. The susceptibility of different regions of the brain to disease are linked to the overstimulation of signals related to the immune system during aging as well as the damaging impact of these cascades on the functionality of different populations of microglia present in each region of the brain. Furthermore a decrease in microglial phagocytosis has been related to many diseases and also has been detected during aging. In this paper we also describe the role of glia in different illness such as AD ALS pain related disorders cancer developmental disorders .

• Y khoa - Dược
• Brain diseases
• Microglia cells during aging
• Transcriptional profiles
• Human cerebral cortex
• Immune system during aging
• Diseases of the brain
• Cerebral infections
• Extramucosal spaces
• The head and neck
• Degenerative spinal disease
• spinal trauma
• Demyelinating diseases
• Spinal cord inflammatory
• Cerebral neoplasms
• A differential diagnostic approach
• Traumatic arterial injuries
• Hemorrhagic vascular pathology
• Acquired demyelinating diseases
• Case Based brain imaging
• Inflammatory disease
• Cerebrovascular diseases
• Primary CNS lymphom
• Pituitary macroadenoma
• Mature pineal teratoma
• Thoái hóa thần kinh
• White matter diseases
• Neurodegenerative Metabolic
• Developmental malformations
• Cranial nerves
• Clinical Neuroscience
• Foundations of Psychological
• Neurodegenerative disorders
• Neurocognitive disorders
• Brain Development
• BMC Cancer
• Brain tumours
• International classification of diseases
• Identify pediatric primary
• Health service
• Arteriovenous malformation
• Brain tumours in children
• Rotating gamma system
• Symptom relief
• Diseases originates
• Brain Trauma
• Invisible Epidemic
• Andre Waters
• Head Injuries
• Grading Concussions
• Blood Clots
• BMC Pediatrics
• Heat stroke
• Heme oxygenase 1
• Cortical brain
• Heat related diseases
• Drivers of Parasitoid
• Wasps Community
• Composition
• Cacao Agroforestry
• Bahia State
• Functional Equilibrium
• Chino Study
• Broken Hearts
• Autoimmune Disease
• Good Nutrition
• Scientific Reductionism
• Molecular Mechanisms
• Neuroprotective Effect
• Cerebral Ischemia
• Brain Regeneration
• Spontaneous Events
• Stem Cells Therapy
• Meets neurology
• Portrayal of diseases
• A founder of neurology in film
• Modern neurologists
• Traumatic brain injury in film
• Multiple sclerosis
• Comprehensive Critical Care
• Critical care infectious diseases
• Respiratory critical care
• Traumatic brain injury
• Neurological criteria
• Neuromuscular disorders
• Neuroinfectious disorders
• Determination of Brain Death
• Isolated seizures
• Status epilepticus