TAILIEUCHUNG - Respiratory and critical care infections - Textbook: Part 2

(BQ) Continued part 1, part 2 of the document Respiratory and critical care infections - Textbook has contents: Parapneumonic pleural effusions, management of multidrug resistant pathogens, scores for the assessment of pneumonia severity and outcome, vaccine preventable respiratory infections, lung infections in cystic fibrosis,. and other contents. Invite you to refer. | CHAPTER 14 Invasive Fungal Infections in Critically Ill Patients Stijn I Blot Koenraad Vandewoude ABSTRACT In the past decades a demographic shift in hospital and intensive care unit ICU populations have been taking place with a greater proportion of strongly debilitated patients who are at risk for secondary opportunistic infections such as invasive fungal disease. e utmost important fungal pathogens encountered in ICUs are invasive candidiasis and invasive pulmonary aspergillosis. With the exception of candidemia the diagnosis of invasive fungal infections is problematic. is may lead to a postponed diagnosis and therefore delayed initiation of antifungal therapy. Despite the availability of potent antifungal agents mortality associated with invasive fungal infections in critically ill patients remains unacceptably high. INTRODUCTION Over the past 3 decades major advances in healthcare have led to an unwelcome increase in the number of life-threatening infections due to true pathogenic and opportunistic fungi. Invasive candidiasis and invasive aspergillosis are the 2 major manifestations of opportunistic invasive 2 ese infections are being seen in ever increasing numbers largely because of the increasing size of the population at risk. is population includes recipients of hematopoietic stem cell transplants and solid organ transplants patients with hematological malignancies patients infected with human immunode ciency virus HIV developing acquired immunode ciency syndrome AIDS and other persons receiving immunosuppressive treatment. Furthermore the use of high-grade supportive care in severe and lifethreatening diseases speci cally in intensive care units ICUs burn patients and premature neonates has improved survival but has created a demographic shift in hospital and ICU populations with more debilitated patients at risk for secondary invasive opportunistic infections. ese evolutions in medical practice have led to changes in the epidemiology of .

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