TAILIEUCHUNG - Intensity modulated radiation therapy in the definitive treatment for cervical and upper thoracic esophageal cancer: Clinical outcome and acute toxicity

To evaluate patient’s characteristics and treatment outcomes of concurrent chemoradiation therapy with intensity modulated radiation therapy technique in upper third esophageal cancer patients. A descriptive perspective study on 32 upper third esophageal cancer patients treated by concurrent chemoradiation therapy with intensitymodulated radiation therapy using simultanous intergrated technique in Department of Radiation Oncology, 108 Military Central Hospital from 2014 to June 2018. | Journal of military pharmaco-medicine no1-2019 INTENSITY-MODULATED RADIATION THERAPY IN THE DEFINITIVE TREATMENT FOR CERVICAL AND UPPER-THORACIC ESOPHAGEAL CANCER: CLINICAL OUTCOME AND ACUTE TOXICITY Duong Thuy Linh1; Pham Thi Hoan1 Nguyen Van Ba1; Tran Viet Tien1 SUMMARY Objectives: To evaluate patient’s characteristics and treatment outcomes of concurrent chemoradiation therapy with intensity modulated radiation therapy technique in upper third esophageal cancer patients. Subjects and methods: A descriptive perspective study on 32 upper third esophageal cancer patients treated by concurrent chemoradiation therapy with intensitymodulated radiation therapy using simultanous intergrated technique in Department of Radiation Oncology, 108 Military Central Hospital from 2014 to June 2018. Results: Diseases were mainly seen in men, aged 40 - 59 years old. Most of the patients were in late stage. 100% histopathology was squamous cell cancer with 50% of moderately differentiation. Radiation schedules were 66 Gy/30fx and 60 Gy/28fx in 25% and 75%, respectively. Chemo 2 2 regimens were cisplatin 75 mg/m and fluorouracil 750 mg/m every 28 days. Full dose chemotherapy was given in . Complete and partial response was seen in and of patients. The 6-month, 1-year, 2-year overall survival rate was , and , respectively. Common toxicities were low hematological toxicity, esophagitis () and dermatis (). Most of them were in grade 1, 2. Conclusions: Concurrent chemoradiation with intensity-modulated radiation therapy technique in upper third esophageal cancer patients had promising results and good tolerence. * Keywords: Upper third esophageal cancer; Concurrent chemoradiotherapy; Intensity-modulated radiation therapy. INTRODUCTION Esophageal cancer ranks seventh in terms of incidence (572,000 new cases) and sixth in mortality overall (509,000 deaths). The latter signifies that esophageal cancer will be responsible for an estimated 1 .

• Y khoa - Dược
• Upper third esophageal cancer
• Concurrent chemoradiotherapy
• Intensity modulated radiation therapy
• Intensitymodulated radiation
• Esophageal cancer patients
• BMC Cancer
• Esophageal cancer
• Neoadjuvant therapy
• Cyclooxygenase 2 inhibition
• Humans suggest
• Esophageal cancer risk
• Whole exome sequencing
• Fastq2vcf modified
• Esophageal squamous cell carcinoma
• Generation sequencing
• 18FDG PET CT simulation
• 3D conformal radiotherapy
• CT simulation in 3D conformal
• Chemo radiotherapy for esophageal cancer
• Definitive chemoradiation
• Acute toxicity
• Irresectable esophageal cancer
• Mental disorder
• Gastric cancer
• Cohort study
• Cancer treatment
• Waiting time
• Narrow band imaging
• Head and neck cancer
• Second primary cancer
• Squamous cell carcinoma
• Prognostic factor
• Controlling nutritional status
• DNA damage repair genes JWA
• Cisplatin based therapy
• Elevated serum YKL 40 levels
• Diagnostic performance
• X ray computed
• Comprehensive positive score
• Gastroesophageal cancer
• Na K 2Cl transporter
• Calculate hazard ratios
• Cancer specific survival
• Extent of lymphadenectomy
• Cutoff value
• Negative lymph nodes
• Cancer specific survival probability
• Elderly patients
• Quality of life
• Clinical trial
• Esophageal carcinoma
• Cancer patients’ outcomes
• Chronic comorbidities
• Angiotensin converting enzyme inhibitors
• Angiotensin receptor blockers
• Survival analysis
• Tumor suppressor candidate 3
• Overall survival
• Human malignancies
• Esophageal neoplasm
• Salvage treatment
• Optimal salvage regimen
• Thoracic esophageal squamous cell carcinoma
• Dietary intake
• Systematic review
• Meta analysis
• Magnetic resonance imaging
• Treatment outcome
• Circulating tumor cells
• Chemotherapeutic efficacy
• Non triploid patient
• Intraoperative ultrasonography
• Recurrent laryngeal nerve nodal metastases
• RLN lymph node dissection
• Steroid therapy
• C reactive protein
• Enhanced recovery after surgery care
• Serum C reactive protein
• Esophageal squamous cell cancer
• Comprehensive geriatric assessment
• Checkpoint inhibitors
• Personalized medicine
• Geriatric oncology
• Risk prediction
• Locoregional recurrence
• Distant metastases