TAILIEUCHUNG - Expression of Ciz1b in patients with non small cell lung cancer

Primary lung cancer is one of the most common malignant diseases. The expression of Ciz1b appears to be limited to tumor cells, suggesting that this variant can be used as a marker for the cancer. This study is to evaluate the expression and diagnostic role of Ciz1b in lung cancer patients. | Journal of military pharmaco-medicine n08-2018 EXPRESSION OF Ciz1b IN PATIENTS WITH NON-SMALL CELL LUNG CANCER Ho Van Son1,2; Ngo Tat Trung1,3; Nguyen Linh Toan1 SUMMARY Introduction: Primary lung cancer is one of the most common malignant diseases. The expression of Ciz1b appears to be limited to tumor cells, suggesting that this variant can be used as a marker for the cancer. This study is to evaluate the expression and diagnostic role of Ciz1b in lung cancer patients. Subjects and methods: 100 patients with non-small cell lung cancer and 51 healthy controls were recruited for this study. Relative expression of Ciz1b mRNA was determined by realtime PCR. Results: Increased Ci1zb mRNA expression was observed in patients with non-small cell lung cancer compared to healthy individuals (p = ). The expression of Ciz1b mRNA was negatively correlated with the ALT enzyme levels (Spearman's r = , p = ) and with the AST levels (Spearman' r = , p = ). The level of mRNA expression of the Ci1zb gene was significantly associated with tumor cell differentiation in patients with non-small cell lung cancer. Ciz1b mRNA expression in serum was capable of distinguishing lung cancer patients from healthy control (AUC = , p = ). Conclusion: The expression of Ciz1b is regulated by the occurrence of lung cancer and Ci1zb plays an important role in lung cancer development, as well as has the potential as a biomarker for diagnosis and prognosis of lung cancer. * Keywords: Lung cancer; Non-small-cell lung carcinoma; Ciz1b; mRNA expression. INTRODUCTION Primary lung cancer is one of the most common malignant diseases and also is one of the leading causes of death from cancers. Lung cancer accounts for about 12% of all types of cancers and 18% of cancer-related deaths [1, 2]. Of these, non-small-cell lung carcinoma (NSCLC) accounts for more than 80% of lung cancer. In Vietnam, lung cancer has increased rapidly due to smoking, air pollution, dust emissions .

• Y khoa - Dược
• Lung cancer
• Non small cell lung carcinoma
• mRNA expression
• Primary lung cancer
• Diagnostic role of Ciz1b
• Lung cancer patients
• BMC Cancer
• Non small cell lung cancer
• Quantitative real time PCR
• Lung squamous carcinoma
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Lung Cancer Screening
• Racial disparities
• Cancer Screening
• Lung Cancer diagnosis
• Screening adherence
• BMC Pulmonary Medicine
• Lung nodule
• Incidental lung nodule
• Interventional pulmonology
• Value of PET CT
• Lymph node in small cell lung cancer
• Organization classification of lung tumours
• Lung cancer risk
• Low dose helical CT screening
• Lung cancer risk test biomarker
• Genome maintenance
• Primary synchronous lung cancer
• Metastatic lung cancer
• Microsatellite analysis
• Tumor lineage
• Lymphocyte ratio
• Advanced lung cancer inflammation index
• Systemic inflammation
• Early stage lung cancer
• Diagnostic tests
• Genetic association
• Chinese population
• Overall lung cancer
• Including lung cancer
• Immune checkpoint inhibitor
• Small cell lung cancer
• Lung inflammation
• Metabolic phenotype
• Pulmonary imaging
• Interstitial lung disease
• Drug induced interstitial lung disease
• Anticancer therapy
• Stereotactic radiotherapy
• Metastatic lung tumor
• Prognostic factor
• Lung development
• Lung adenocarcinoma
• Overall survival
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Deleted in liver cancer 1
• Cancer related mortality
• Radiation therapy
• ABC of lung cancer
• Malignant pleural mesothelioma
• Service organization
• Performance analysis of lung cancer diagnosis algorithms on X Ray images
• Lung cancer diagnosis algorithms on X Ray images
• X Ray images
• Characterize lung cancer
• K Nearest Neighbor
• Distal metastases
• Therapeutic potential
• Human lung cancer
• SK MES 1 lung carcinoma cell growth
• Health inequalities
• Carbon monoxide
• Lung health check
• Multivariate regression analysis
• Multiple myeloma
• Occult lung cancer
• Non small cell lung cancer
• Tumor lymph node metastasis
• Stage I IIIA
• Surgical outcome
• Pulmonary disease
• Patients with lung cancer
• C T1N0M0 primary lung cancer