TAILIEUCHUNG - Evaluation of subchronic toxicity of Tri Thien Duoc hard capsule in experimental animals

The rats were treated with the doses of g extract/kg per day and g extract/kg per day for a period of 90 consecutive days. Tri Thien Duoc hard capsule caused no significant dose-related changes in general status, hematological parameters, renal and hepatic function tests; in addition, it did not cause any change in histology of the liver and kidney of the rats. Our finding obtained that the Tri Thien Duoc hard capsule did not cause subchronic toxicity in experimental animals. | JOURNAL OF MEDICAL RESEARCH EVALUATION OF SUBCHRONIC TOXICITY OF TRI THIEN DUOC HARD CAPSULE IN EXPERIMENTAL ANIMALS Nguyen Thi Thanh Loan1, Pham Thi Van Anh1, Vu Thi Ngoc Thanh1, Nguyen Thi Ngoc Tram2 1 Ha Noi Medical University Thien Duoc Limited Company 2 Tri Thien Duoc, a formulation of Portulaca oleracea L. and Amaranthus spinosus L., is aimed to treat hemorrhoids and other related conditions; however, the safety of this product’s long-term consumption has never been reported. The present study evaluated the subchronic toxicity of Tri Thien Duoc hard capsule in experimental animals. Subchronic toxicity was studied in Wistar rats based on the guidance of World Health Organization and Organisation for Economic Co-operation and Development. The rats were treated with the doses of g extract/kg per day and g extract/kg per day for a period of 90 consecutive days. Tri Thien Duoc hard capsule caused no significant dose-related changes in general status, hematological parameters, renal and hepatic function tests; in addition, it did not cause any change in histology of the liver and kidney of the rats. Our finding obtained that the Tri Thien Duoc hard capsule did not cause subchronic toxicity in experimental animals. Keywords: Tri Thien Duoc, subchronic toxicity, experimental animals I. INTRODUCTION mixed hemorrhoids [5; 6]. Treatment of sympHemorrhoids are a very common anorectal tomatic hemorrhoids ranges from dietary disorder defined as the symptomatic enlarge- advice, lifestyle modification and pharmacol- ment and abnormally downward displacement ogical approaches to office-based procedures of anal cushions. They affect millions of and radical surgery depending on their grade people around the world and represent a and severity [7]. Treatment of hemorrhoids in major medical and socioeconomic problem [1; modern medicine is still in its infancy. Due to 2]. Hemorrhoids usually present with itching, limited modern pharmacotherapeutic .

• Y khoa - Dược
• Journal of medical research
• Evaluation of subchronic toxicity
• Tri Thien Duoc hard capsule in experimental animals
• Tri Thien Duoc
• Significant dose related changes
• Subchronic toxicity in experimental animals
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