TAILIEUCHUNG - Co-precipitation microwave assisted synthesis of Fe3O4 nanoparticles for drug delivery system

In this study, Fe3O4 magnetic nanoparticles were prepared by the co-precipitation of Fe3+ and Fe2+ with the assistant of microwave (MW) irradiation. The crystal and magnetic properties of the Fe3O4 particles obtained from different conditions of microwave reaction were examined. | Lê Thị Thu Hương và Đtg Tạp chí KHOA HỌC & CÔNG NGHỆ 190(14): 61 - 68 CO-PRECIPITATION MICROWAVE-ASSISTED SYNTHESIS OF Fe3O4 NANOPARTICLES FOR DRUG DELIVERY SYSTEM Le Thi Thu Huong1, 2, Le Mai Huong3, Tran Thi Hong Ha , Pham Hong Nam1, Ha Phuong Thu1* 3 1 Institute of Materials Science - VAST Vietnam National University of Agriculture, 3 Institute of Natural Product Chemistry - VAST 2 ABSTRACT In this study, Fe3O4 magnetic nanoparticles were prepared by the co-precipitation of Fe3+ and Fe2+ with the assistant of microwave (MW) irradiation. The crystal and magnetic properties of the Fe3O4 particles obtained from different conditions of microwave reaction were examined. The prepared magnetic nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission and scanning electron microscopy (TEM & SEM), X-ray powder diffraction (XRD), vibrating sample magnetometer (VSM) and Dynamic Light Scattering (DLS). After that, the optimized Fe3O4 magnetic nanoparticles (size of 10-15 nm, the saturation magnetization of 69 emu/g, and zeta potential of mV) were surface modified by alginate polymer and attached with a cancer drug Doxorubicin. The magnetic inductive heating effects and anticancer activities of the nano drug system showed that the synthesis of Fe 3O4 with microwave-assistant maintains both physical and biological properties of the material. Keywords: microwave assisted synthesis; coprecipitation; Fe3O4 nanoparticles; drug delivery system;, Doxorubicin INTRODUCTION* Fe3O4 nanoparticles have been extensively investigated for their applications in biomedicine as well as other fields. There are a variety of methods for Fe3O4 preparation reported in the literature to prepare Fe3O4 nanoparticles such as co-precipitation [1], high-power milling [2], sol-gel [3] or microfluid engineering [4]. The help of microwave in the synthesis of the Fe3O4 nanoparticles have been used in different methods due to many advantages of .

• Hoá học
• Microwave assisted synthesis
• Fe3O4 nanoparticles
• Drug delivery system
• Co precipitation microwave
• Vibrating sample magnetometer
• Scanning electron microscopy
• A simple microwave assisted method
• Microwave assisted method
• Synthesis of Thalidomide
• L glutamic acid
• Presence of 4 dimethyl aminopyridine
• Journal of Science and Technology
• Simple synthesis of graphene nanosheets
• Microwave–assisted method
• Few–layer–graphene
• Microwave radiation and sonication process
• Long Chain Arylpiperazines
• Solvent free synthesis
• Food and Drug Administration
• Phase Transfer Catalysts
• Journal of Chemistry
• Glycerol utilization
• Pyridine synthesis
• Value added chemicals
• Wittig reaction
• Microwave assisted
• One pot synthesis
• Heterogeneous catalysis
• Microwave irradiation
• Ethylene glycol
• Molybdenum trioxide
• Rapid microwave
• Assisted synthesis
• Molybdenum trioxide nanoparticles
• Undergraduate experiment using microwave Assisted synthesis of first Raw metalloporphyrins
• Characterizations and spectroscopic study
• Quantum chemical calculations
• The provided theoretical data
• Synthesis of some 2 amino 4
• 6 diarylpyrimidine derivatives
• Corresponding substituted chalcones
• Mass spectral data
• Two different synthetic methods
• Synthesis and characteristics
• La0
• 6Sr0
• 4Co0
• 2Fe0
• 8O3 δ perovskite cathode material
• Microwave assisted sol – gel method
• Gadolinium doped ceria
• Resistance of cathode
• Microwave assisted direct synthesis
• 5 alkyl 2 amino 1 3 4 thiadiazoles
• The MW mediated solvent free method
• The reaction mixture
• Thiosemicarbazide and concentrated sulfuric acid
• Solvent free reaction
• Antifungal activity
• 4 Thiazolidinone
• Possible bioactive agents
• BMC Chemistry
• Structure–activity relationship
• Hydrazone moiety
• Nanorod hydroxyapatite from eggshells
• Power of microwaves were investigated
• Obtained hydroxyapatite
• X ray diffraction
• (7 (trifluoromethyl)quinolin 4 yl)oxy groups
• Second generation photosensitizers
• Aggregation phenomena
• 1 2 4 Triazolo[4 3 a]pyridine
• Green chemistry
• 3 chloro 2 hydrazinylpyridine
• Pyrimidinic hydrazides
• Naphthopyranopyrimidinones derivatives
• Conventional synthesis
• 1 3 dipolar cycloaddition
• Benzothiophene dioxide
• Amyotrophic lateral sclerosis (ALS)
• Multicomponent reactions
• p TSA
• Benzo[a]pyrimido[5’
• 4’:5
• 6]pyrido[2
• 3 c ]phenazine
• Microwave assisted organic
• Antiinflammatory activities
• Antibacterial agent
• Green synthesis
• Parkia speciosa Hassk
• Extract of Parkia speciosa Hassk
• Microwave reactions
• Zinc and copper oxide nanoparticles
• Malva parviflora L (Millow)
• Chemical precipitation
• Microwave assisted technique
• Biginelli reactions
• Antimicrobial activity
• Thiazolopyrimidine derivatives
• Copper triflate
• Microwave assisted claisen schmidt condensation
• Arylmethyl ketones
• Aryl aldehydes catalyzed by Cu
• Solvent free conditions
• Imidazo[1
• 2 a]pyrimidine
• Tri/tetrasubstituted imidazole
• Microwave synthesis
• One pot reaction
• p toluenesulfonic acid
• Expeditious synthesis
• Cytotoxicity and antifungal activities
• Antifungal activities