TAILIEUCHUNG - Ebook Atlas of pulmonary cytopathology: Part 2

(BQ) Part 2 book “Atlas of pulmonary cytopathology” has contents: Benign lung neoplasms, malignant lung neoplasms, unusual and metastatic lesions. | 5 Benign Lung Neoplasms 81 82 Figure — Papillomatosis, Bronchial Brushing [Pap Stain; Low Power]. Three-dimensional bifurcating papillary stalks are immediately noticeable in this large microfragment of tissue. Single cells exfoliated from these branching fronds are also numerous. These neoplasms may be solitary or multiple and are more likely in children and adolescents, but may occur in adults also. As squamous papillomas arise in both major and minor bronchi, their exophytic polypoid-like protrusions into the bronchial lumen allow for this florid architectural branching. Atlas of Pulmonary Cytopathology Figure — Papillomatosis, Bronchial Brushing [Pap Stain; High Power]. High power magnification shows cells that have exfoliated as single forms and in loose clusters. Cells have the appearance of squamous metaplasia with a modest amount of opaque cytoplasm and rounded nuclei. Admixed with these metaplastic squamous cells are histiocytes and an occasional ciliated bronchial cell. The inset shows evenly dispersed nucleoplasm and smooth nuclear outlines. Though not present in this field, koilocytic change typical of low-grade squamous intraepithelial lesions would not be unusual because of the well-established association of pulmonary squamous papilloma with low-risk human papillomavirus, particularly human papillomavirus-6 and human papillomavirus-11. Figure — Papillomatosis, Resection [H&E Stain; Low Power]. Tracheobronchial papillomatosis is an uncommon complication of laryngeal disease. The papillomas harbor human papillomavirus types 6 or 11, and are morphologically similar to the laryngeal lesions. This endobronchial biopsy shows characteristic fragments of acanthotic squamous epithelium covering a hyalinized fibrovascular core. The oriented fragments show orderly maturation. Bronchoscopically, the mucosa may appear velvety or shaggy; postobstructive inflammatory changes and even bronchiectasis may supervene. Chapter 5: Benign Lung .

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