TAILIEUCHUNG - (mebooksfree.com)phy&pha&ana&cro&plu&2nd 2

C:/ITOOLS/WMS/CUP-NEW/4466933/WORKINGFOLDER/CRSS/ [175–200] 11:28AMSection [175–200] 11: [175–200] 11:28AMAbsorption, distribution and is the study of how the body handles a is comprised of several different areas. Firstly there are processes such , distribution, metabolism and excretion, which are sometimes as the ADME scheme. Secondly there are various pharmacokinetic measurements which are described by equations. This area is called metrics. Thirdly the analysis of measured data from in vivo pharmacokinetic studies. is done by modelling which may be compartmental, physiological compartmental. This section covers each of these areas in uptake of substances into or across drug administration it usually refers to uptake into the blood stream via route of administration such as oral, intramuscular or reversible transfer of a substance from one location to another to a particular tissue will depend upon:.Factors influencing the passage of drug across a blood flow. A substance will initially be distributed to tissues regional blood flow such as the brain and kidneysVascular may be quantified by assessing the volume of distribution of a drug.(see below) movement of a substance from an area of high regional blood flow area of medium or low regional blood flowC:/ITOOLS/WMS/CUP-NEW/4466933/WORKINGFOLDER/CRSS/ 6178 [175–200] 11:28AM. PharmacokineticsThis phenomenon may determine the duration of action of a drug. For example,.thiopentone is rapidly redistributed from its site of action, the highly , to other tissues, leading to a short duration of action. Factors distribution of a substance will also affect its redistribution. For example,.highly lipid soluble drugs move rapidly across membranes and so are more and redistributedC:/ITOOLS/WMS/CUP-NEW/4466933/WORKINGFOLDER/CRSS/ [175–200] 11:28AMFirst pass bioavailabilityThe degree of metabolic breakdown of an orally administered drug in the intestine or liver before it reaches the systemic is also known as the first pass effect and results in a reduction in the concentration of the drug. Drugs which are subject to first pass metabolism , buprenorphine, diazepam and midazolam. The process of first can be exploited drug that is converted from an inactive form to an active form by is an example of a pro drug and undergoes demethylation to morphine,.which is its pharmacologically active fraction of drug that reaches the circulation compared with the given intravenously. (%). ratio of the area under the stated concentration–time curve (AUC).divided by the area under the . concentration–time curve. (%).

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