TAILIEUCHUNG - The effects of midazolam and etomidate on the antioxidant system in the rat liver

This study was conducted to investigate the histopathological and biochemical effects of midazolam and etomidate, which are intravenous anesthetics used in surgical operations, on rat liver. There were 3 study groups each consisting of 9 animals: the control, midazolam, and etomidate groups. | Turkish Journal of Biology Turk J Biol (2015) 39: 865-871 © TÜBİTAK doi: Research Article The effects of midazolam and etomidate on the antioxidant system in the rat liver 1, 1 2 3 4 5 Dilek BAYRAM *, Meral ÖNCÜ , Efkan UZ , Hacı Ramazan YILMAZ , Ayşe YİĞİT , Ahmet KOÇAK Department of Histology and Embryology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey 2 Department of Biochemistry, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey 3 Department of Medical Biology, Faculty of Medicine, Mevlana University, Konya, Turkey 4 Department of Medical Genetics, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey 5 Department of Histology and Embryology, Faculty of Medicine, Dumlupınar University, Kütahya, Turkey 1 Received: Accepted/Published Online: Printed: Abstract: This study was conducted to investigate the histopathological and biochemical effects of midazolam and etomidate, which are intravenous anesthetics used in surgical operations, on rat liver. There were 3 study groups each consisting of 9 animals: the control, midazolam, and etomidate groups. Midazolam and etomidate were administered 10 times with 1-day intervals. At the end of the study, tissues were taken for histological examination and biochemical analysis. We determined superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels in the liver. There was a slight increase in MDA level in the midazolam-exposed group when compared with the controls, and this was not statistically significant. However, SOD and CAT activities were significantly increased in the midazolam group. We found slight damage in histological sections in parallel to biological findings. MDA levels were significantly increased in the etomidate group and SOD and CAT activities were also prominent in this group. More histological changes like hepatocyte degeneration, .

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