TAILIEUCHUNG - Characterization of crilin and nanocurcumin’s synergistic effect on treatment for 7.12 dimethylbenz[a]anthracene (DMBA) induced breast cancer mice

In this study, we established the mouse model of breast cancer induced by DMBA and evaluated the effectiveness of the combination of crilin and nanocurcumin in treatment of breast cancer. After a 12-week coadministration of crilin and nanocurcumin, the DMBA-induced mice’s body weight and the number of erythrocytes and leukocytes in their blood reversed. Furthermore, the synergistic effect of crilin and nanocucumin on reduction in the tumor volume was proven. | VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 34, No. 1 (2018) 61-73 Characterization of Crilin and Nanocurcumin’s Synergistic Effect on Treatment for [a]anthracene (DMBA)-Induced Breast Cancer Mice Tran Gia Buu*, Tran Thi Phuong Nhung, Nguyen Thi Trang Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, 12 Nguyen Van Bao, Go Vap, Ho Chi Minh City, Vietnam Received 30 February 2018 Revised 14 April 2018; Accepted 12 June 2018 Abstract: Breast cancer is the neoplastic disease which is characterized by unregulated ductal and lobular hyperplasia. Some herbal remedies have proved the inhibitory effect on breast cancer, such as crilin-extracted from Cirnum latifolum and curcumin-isolated from Cucuma longa. However, the synergistic effect of crilin and nanocurcumin has not been studied so far. In this study, we established the mouse model of breast cancer induced by DMBA and evaluated the effectiveness of the combination of crilin and nanocurcumin in treatment of breast cancer. After a 12-week coadministration of crilin and nanocurcumin, the DMBA-induced mice’s body weight and the number of erythrocytes and leukocytes in their blood reversed. Furthermore, the synergistic effect of crilin and nanocucumin on reduction in the tumor volume was proven. Histological analysis revealed that co-administration of crilin and nanocurcumin inhibited the expansion of mammary ductal carcinoma cells into surrounding tissues, recovered lobular cells structure, and diminished leukocyte composition. Thereby, the combination of crilin and nanocurcumin helped recover immune system and prevent further development of breast cancer. Keywords: Breast cancer, DMBA, Cirnum latifolum, nanocucumin, synergistic effect. 1. Introduction one of ten new cancer patients throughout the world each year are related into breast cancer with more than million cases and over 410,000 deaths annually [1]. The .

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