TAILIEUCHUNG - Lycium barbarum L. (goji berry) fruits improve anxiety, depression-like behaviors, and learning performance: The moderating role of sex

The aim of this research was to investigate the effects of the methanol extract obtained from Lycium barbarum fruits on anxiety, depression-like behaviors, and spatial memory in Wistar albino rats. | Turkish Journal of Biology Turk J Biol (2016) 40: 762-771 © TÜBİTAK doi: Research Article Lycium barbarum L. (goji berry) fruits improve anxiety, depression-like behaviors, and learning performance: the moderating role of sex 1,2, 3 2 2 Fatma PEHLİVAN KARAKAŞ *, Hamit COŞKUN , Kadir SAĞLAM , Bihter Gökçe BOZAT Department of Field Crops, Faculty of Agriculture and Natural Sciences, Abant İzzet Baysal University, Bolu, Turkey 2 Department of Biology, Faculty of Science and Art, Abant İzzet Baysal University, Bolu, Turkey 3 Department of Psychology, Faculty of Science and Art, Abant İzzet Baysal University, Bolu, Turkey 1 Received: Accepted/Published Online: Final Version: Abstract: The aim of this research was to investigate the effects of the methanol extract obtained from Lycium barbarum fruits on anxiety, depression-like behaviors, and spatial memory in Wistar albino rats. A total of 28 rats were selected, randomly assigned to four experimental groups, and tested by means of the open field and elevated plus maze tests for anxiety-like behaviors, the forced swim test for depression-like behaviors, and the Morris water maze test for spatial memory. The findings demonstrated that in the open field, L. barbarum-administered rats spent more time at the center and showed more mobility and velocity than controls. In the elevated plus maze, L. barbarum-administered rats spent more time in the open arms, spent less time in the closed arms, and showed more mobility and velocity. In the Porsolt test, L. barbarum-administered rats showed less immobility. In the Morris water maze, L. barbarumadministered rats took more time to find the platform. However, females were better at finding the platform than males. The methanol extract of L. barbarum fruits decreased anxiety and depression-like behaviors and interacted with sex on spatial memory. Key words: Lycium barbarum (goji

• Sinh học
• Lycium barbarum
• Spatial memory
• Wistar albino rat
• Depression like behaviors
• Morris water maze
• BMC Chemistry
• Goji berry
• Lycium ruthenicum
• Monomeric anthocyanin
• BMC Plant Biology
• Fruit development
• Gene expression
• L ruthenicum
• Journal of Biology
• Lycium barbarum L
• Pharmacological activity
• Antioxidant enzymes
• Lycium barbarum fruits
• Immunohistochemical staining
• L barbarum
• Fruit color
• Anthocyanin biosynthesis
• Toned milk
• Vitamin D
• Polyphenolic extract
• Vitamin D stability in yoghurt
• Ethanolic goji berry
• BMC Genomics
• Illumina sequencing
• Anthocyanin synthesis
• Sugar metabolism
• MYB transcription factor
• BMC Veterinary Research
• Qinling giant panda
• Sperm quality
• Freezing medium
• Ailuropoda melanoleuca
• White adipose tissue
• Total distance travelled
• Leptin hormone
• Alzheimers disease
• NF κB pathway
• Frequency electromagnetic field
• Raf 1 kinase inhibitor protein
• Rat hippocampus
• Diclofenac sodium
• Learning and memory
• Sensory motor tests
• Morris water maze test
• Traumatic brain injury
• Thromspondin 1
• Neurological severity score
• Blood brain barrier