TAILIEUCHUNG - Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake
Acrylamide has neurotoxic, mutagenic, and genotoxic effects in humans and experimental animals. Fruit consumption is important for human health, because fruits are the source of many nutrients such as vitamins, minerals, carotenoids, dietary fiber and phytonutrients. | Turkish Journal of Biology Turk J Biol (2015) 39: 872-878 © TÜBİTAK doi: Research Article Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake 1, 2 3 4 Mehmet Erman ERDEMLİ *, Zümrüt DOĞAN , Yılmaz ÇİĞREMİŞ , Müslüm AKGÖZ , 5 4 1 Eyüp ALTINÖZ , Murat GEÇER , Yusuf TÜRKÖZ 1 Department of Medical Biochemistry, Faculty of Medicine, İnönü University, Malatya, Turkey 2 Department of Anatomy, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey 3 Department of Medical Biology and Genetics, Faculty of Medicine, İnönü University, Malatya, Turkey 4 Bioanalysis Laboratory, TÜBİTAK National Metrology Institute, Gebze, Kocaeli, Turkey 5 Department of Medical Biochemistry, Faculty of Medicine, Karabük University, Karabük, Turkey Received: Accepted/Published Online: Printed: Abstract: Acrylamide (AA) has neurotoxic, mutagenic, and genotoxic effects in humans and experimental animals. Fruit consumption is important for human health, because fruits are the source of many nutrients such as vitamins, minerals, carotenoids, dietary fiber, and phytonutrients. Many agricultural products provide natural melatonin in the diet. At the onset of the study, rats were weighted and randomly divided into four groups each containing 10 rats as follows: group 1: control (fed with normal diet and normal drinking water); group 2: apricot (fed with a daily diet with 5% apricot and normal drinking water); group 3: AA (administered daily acrylamide at 500 µg/kg . via drinking water and fed a normal diet); group 4: apricot-AA (administered daily acrylamide at 500 µg/kg . via drinking water and fed with a diet with 5% apricot). The diet schedule was continued for 12 weeks. At the end of the study, samples of large intestine were collected for biochemical analyses. The highest lipid peroxidation (as malondialdehyde, MDA) levels were .
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