TAILIEUCHUNG - The triterpenoid and steroid from the fruiting body of ganoderma applanatum (Pers.) pat. in Viet Nam

Five compounds, ergosterol (1), 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (2); ergosta-7,22-dien-3β-ol (3); lanosta-7,9(11),24-triene-3,26-diol (4) and 3β-hydroxy-5α-lanosta7,9,24(E)-trien-26-oic acid (5) were isolated from fruiting body of Ganoderma applanatum (Pers.) Pat. (Ganodermataceae). The structures of the isolated compounds were established by spectroscopic methods (MS, 1H-NMR, 13C-NMR, DEPT). | Vietnam Journal of Science and Technology 56 (5) (2018) 550-556 DOI: THE TRITERPENOID AND STEROID FROM THE FRUITING BODY OF Ganoderma applanatum (Pers.) Pat. IN VIET NAM Hoang Van Trung1, Nguyen Tan Thanh1, Nguyen Ngoc Tuan2, Doan Manh Dung3, Tran Dinh Thang1, * 1 School of Chemistry, Biology and Environment, Vinh University, Vinh City 2 Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Ho Chi Minh City 3 Hue University of Science- Hue University, 77 Nguyen Hue, Hue City * Email: thangtd@ Received: 25 May 2018; Accepted for publication: 5 September 2018 Abstract. Five compounds, ergosterol (1), 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (2); ergosta-7,22-dien-3β-ol (3); lanosta-7,9(11),24-triene-3,26-diol (4) and 3β-hydroxy-5α-lanosta7,9,24(E)-trien-26-oic acid (5) were isolated from fruiting body of Ganoderma applanatum (Pers.) Pat. (Ganodermataceae). The structures of the isolated compounds were established by spectroscopic methods (MS, 1H-NMR, 13C-NMR, DEPT). Keywords: Ganoderma applanatum, Ganodermataceae, triterpenoid, steroid, lanosta-7,9(11),24triene-3,26-diol. Classification numbers: ; . 1. INTRODUCTION “Linh chi” - the Vietnamese name for Ganoderma can be used in the prevention and treatment of various types of disease. Various compounds have been isolated from the fruiting bodies, spores, gills, and mycelia of many Ganoderma mushrooms. Ganoderma contains many bioactive natural components, including triterpenes, steroid, polysaccharides, proteins, and unsaturated fatty acids [1-5]. It has been identified as new potent lead structures for the development of novel pharmaceuticals against infectious diseases, cancer, and other diseases. The majority of biological activities are its immunomodulatory and antitumor activities [1–8]. The majority of triterpenes and steroid of Ganoderma exhibit a wide range of biological activities, including antitumor, .

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