TAILIEUCHUNG - Microwave-assisted extraction of Taxol and 10-deacetylbaccatin III from the leaves and branches of red pine (Taxus wallichiana Zucc.)
In this study, the extraction of Taxol and 10-DAB III from the leaves and branches of red pine cultivated in Lam Dong Province, Vietnam was carried out. Some traditional methods such as Soxhlet, maceration as well as the modern methods such as microwave-assisted extraction (MAE), ultrasonic-assisted extraction (UAE) were used to extract and evaluate the extraction efficiency. | SCIENCE & TECHNOLOGY DEVELOPMENT, Vol 19, 2016 Microwave-assisted extraction of Taxol and 10-deacetylbaccatin III from the leaves and branches of red pine (Taxus wallichiana Zucc.) Le Thi Kim Phung1 Vu Thi Hong Quan1 Nguyen Thi Ngoc Tuyet1 Tran Anh Khoa2 Le Anh Kien3 1 Ho Chi Minh city University of Technology – VNU-HCM Hochiminh City University of Natural Resources and Environment 2 3 Institute for Tropicalisation and Environment, HCMC (Manuscript Received on July, 2016, Manuscript Revised on September, 2016) ABSTRACT Taxol has been by far the most well-known worldwide as an effective anticancer natural to extract and evaluate the extraction efficiency. The concentration of 10-DAB III experienced at drug. With the great treatment abilities at low concentration, Taxol is a considerable interest over 90% as compared to maceration and the amount of Taxol accounted for approximately of many scientists in various fields. The 80% of Soxhlet. MAE was thus more suitable for commercial products of Taxol can be isolated directly from Taxus species or can be recovering both Taxol and 10-DAB III than the others because of its short time and less solvent synthesized from 10-deacetylbaccatin III (10DAB III) or baccatin III (BC III), which are consumption. Besides, four parameters including solvent nature (MeOH and EtOH), known as precursors of Taxol, by using semisynthetic methods. In this study, the extraction time, material/solvent ratio (1:10, 1:15, 1:20 and 1:25) and microwave power extraction of Taxol and 10-DAB III from the (40W, 240W and 440W) were investigated the leaves and branches of red pine cultivated in Lam Dong Province, Vietnam was carried out. effects of these elements on the content of 10DAB III and Taxol. The results illustrated that Some traditional methods such as Soxhlet, maceration as well as the modern methods such the optimal conditions providing 10DAB III were as follows: 240W, 1:15 ratio .
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