TAILIEUCHUNG - Pt(IV), Pd(II), and Rh(III) complexes induced oxidative stress and cytotoxicity in the HCT-116 colon cancer cell line
The use of transition metal complexes as appropriate analogues to cisplatin and similar anticancer drugs nowadays is of utmost importance. The inertness of Pt(IV), Pd(II), and Rh(III) complexes and the choosing of convenient ligands could offer a possible advantage in comparison to Pt(II) complexes. | Turkish Journal of Biology Turk J Biol (2017) 41: 141-147 © TÜBİTAK doi: Research Article Pt(IV), Pd(II), and Rh(III) complexes induced oxidative stress and cytotoxicity in the HCT-116 colon cancer cell line 1 2 3 3 3, Petar ČANOVIĆ , Jovana BOGOJESKI , Jelena V. KOŠARIĆ , Snežana D. MARKOVIĆ , Marko N. ŽIVANOVIĆ * 1 Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia 2 Department of Chemistry, Faculty of Science, University of Kragujevac, Kragujevac, Serbia 3 Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, Serbia Received: Accepted/Published Online: Final Version: Abstract: The use of transition metal complexes as appropriate analogues to cisplatin and similar anticancer drugs nowadays is of utmost importance. The inertness of Pt(IV), Pd(II), and Rh(III) complexes and the choosing of convenient ligands could offer a possible advantage in comparison to Pt(II) complexes. These advantages could be attributed to the better anticancer activity and fewer possible side effects. In this paper, we have chosen three complexes of different transition metal ions, [(TLtBu)PdIICl]ClO4, [RhIII(LH2tBu)Cl3], and [PtIV(LH2tBu)Cl3]Cl (where TLtBu is 2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and LH2tBu is 2,6-bis(5-tert-butyl1H-pyrazol-3-yl)pyridine), for biological tests. All three complexes exerted strong prooxidative and cytotoxic effects on the human colorectal colon cancer HCT-116 cell line. The Pd(II) complex showed the most significant effect, while the Rh(III) complex showed the least effect. Key words: Anticancer activity, colon cancer, cytotoxicity, oxidative stress, palladium, platinum, rhodium 1. Introduction Cancer is the second leading cause of death after cardiovascular diseases, and finding the appropriate therapy is of key medical and scientific interest, with a potentially substantial .
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