TAILIEUCHUNG - Study of the preventive effect of anti-urease IgY on helicobater pylori infection in white mice

The aim of this study is to evaluat the inhibitory effect of IgY against H. pylori-derived urease on H. pylori in experimental animals. | JOURNAL OF MILITARY PHARMACO-MEDICINE N09-2017 STUDY OF THE PREVENTIVE EFFECT OF ANTI-UREASE IGY ON HELICOBACTER PYLORI INFECTION IN WHITE MICE Do Hoang Long*; Do Minh Trung**; Vi Thuat Thang***; Tran Ngoc Dung*** Le Thu Hong***; Le Van Dong**; Nguyen Anh Tuan** SUMMARY Objectives: Urease inhibition with oral specific antibody is a new approach in prevention and treatment of Helicobacter pylori infection. This research aimed to investigate the preventive effect of anti-urease IgY on H. pylori infection in experimental animal. Subjects and method: White mice were prophylactic treated by having food with or without anti-urease IgY a week before H. pylori inoculation and continuously till end of the monitoring time. Nine weeks after the start of the diet, the mice were examined to determine the reactivity of anti-H. pylori IgG in serum and the inflammation and infection status of the stomach biopsy. Results: There were significant differences in the anti-H. pylori IgG titer, the eradication of H. pylori and the reduction of H. pylori-associated gastritis between the two groups of infected mice. Conclusion: Oral administration of urease-specific IgY prevented H. pylori colonization in the inocculated mice. * Keywords: Helicobacter pylori; Anti-urease IgY; Oral passive immunization; Preventive effect. INTRODUCTION In Vietnam as well as in the world, Helicobacter pylori (H. pylori) infection accounts for 75 - 95% of all causes of gastritis and peptic ulcer disease, in which urease secreted by the bacteria is essential for the survival of the bacteria, facilitating the bacteria's invasion into the gastric mucosa [4]. In spite of new antibiotics to be used recently, failure in treatment of H. pylori induced gastritis and duodenal ulcer is common, due to the antibiotic resistance of the bacteria, especially in the developing and least developed countries [5, 7]. Since then, prophylactic treatment with drug or food containing compound that inhibite the bacteria before .

• Y học thường thức
• Oral passive immunization
• The effect of diet containing IgY against urease
• Anti H
• pylori antibody in H
• pylori infected mice
• Gastric mucosa inflammation in mice
• Gsubmucosa’s bacterial density
• Animal model of H
• pylori infection on Swiss mice