TAILIEUCHUNG - Ebook Neuromuscular disorders (2/E): Part 2

(BQ) Part 2 book “Neuromuscular disorders” has contents: Toxic neuropathies, neuropathies associated with endocrinopathies, idiopathic polyneuropathy, autoimmune myasthenia gravis, muscular dystrophies, congenital myopathies, metabolic myopathies, mitochondrial disorders, and other contents. | CHAPTER 20 Toxic Neuropathies This chapter reviews neuropathies associated with various drugs and other environmental exposures (Table 20-1). Toxic neuropathies due to chemotherapeutic agents are discussed in Chapter 19. The associated neuropathy for most of these is an axonal, length-dependent predominantly sensory neuropathy. The history of exposure and sometimes the involvement of other organ systems help to suggest the correct diagnosis. Although we mention features that have been reported on nerve biopsy, this is not typically part of the workup as in most cases the abnormalities are nonspecific. ►► TOXIC NEUROPATHIES ASSOCIATED WITH MEDICATIONS Pathogenesis The pathogenic basis of the neuropathy is not known. Some have found that metronidazole binds to DNA and/or RNA, which could lead to breaks and impair transcription or translation to normal Others have speculated that toxicity may arise from the production of nitro radical anions that bind and disrupt normal protein/enzyme Furthermore, the histological abnormalities in metronidazole-treated rodents and abnormalities on brain MRI scans in patients with metronidazole-associated encephalopathy resemble thiamine (vitamin B1) deficiency. It has been postulated that there may be enzymatic conversion of metronidazole to an analog of thiamine, which may act as a B1 METRONIDAZOLE MISONIDAZOLE Clinical Features Clinical Features Metronidazole is used to treat a variety of protozoan infections and Crohn –8 Metronidazole is a member of the nitroimidazole group and has been associated with hyperalgesia and hypesthesia in a length-dependent pattern. Autonomic dysfunction may develop as well. Motor strength is typically normal. The cumulative dose at which neuropathy occurs is wide, ranging from to 228 g. Although there is no clear dose effect, neuropathy appears to occur more frequently in patients receiving greater than g daily of metronidazole for 30 or .

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• Neuromuscular disorders
• Toxic neuropathies
• Neuropathies associated
• Congenital myopathies
• Metabolic myopathies
• Mitochondrial disorders
• Neuromuscular Junction
• Neuromuscular Transmission
• Presynaptic Disorders
• Postsynaptic Disorders
• Oxford textbook of neuromuscular disorders
• Autonomic neuropathies
• Multiple mononeuropathies
• Diabetic neuropathy
• Peripheral nerve hyperexcitability disorders
• Inherited myasthenic syndromes
• Myasthenia gravis
• Endocrine myopathies
• BMC Anesthesiology
• Neuromuscular diseases
• Neuromuscular blockade
• Modified gamma cyclodextrin
• Motor neurone disorders
• Amyotrophic lateral sclerosis
• Immunomodulating treatment
• Other motor neuron disorders
• Spinal muscular atrophies
• BMC Musculoskeletal Disorders
• Ankle sprains
• Neuromuscular training
• Musculoskeletal system
• General practitioner
• Knee osteoarthritis
• Total knee replacement
• Randomized controlled trial
• Running biomechanics
• Load carriage
• Randomized clinical trial
• Resistance training
• Vertebral body
• Idiopathic scoliosis
• Neuromuscular scoliosis
• Aberrant asymmetrical vertebral growth
• Diagnosis in orthopaedics
• Onflammatory rheumatic disorders
• Endocrine bone disorders
• Peripheral nerve disorders
• Orthopaedic operations
• Musculoskeletal disorders
• Metabolic disorders
• Psychiatric disorders
• Surgical conditions
• Behavioural problems
• Common forearm surgeries
• Textbook of orthopedics
• Congenital disorders
• Developmental disorders
• Skeletal tuberculosis
• Rheumatic diseases
• Respiratory disease
• Neuromuscular disease
• Pediatric intensive care
• Gastrointestinal disorders
• Hematologic disorders
• Cardiac disease
• Ghai essential pediatrics
• Respiratory system
• Central Neuromuscular disorders
• Childhood malignancies
• Neuroinfectious disorders
• Determination of Brain Death
• Isolated seizures
• Status epilepticus
• Millers textbook
• Anesthetic implications
• Alternative medications
• Patient positioning
• Associated risks
• Genetic disorders
• Energy Technique
• Anatomic Regions
• Etiology
• Mechanisms
• Terminology
• Manipulable Disorders
• Neuromuscular Physiology
• Manual of neurologic therapeutics
• Neurologic therapeutics
• Peripheral neuropathies
• Neuromuscular junction disorders
• Motor neuropathies
• Other demyelinating diseases
• The short textbook
• Pediatric endocrinology
• Pediatric envenomations
• Pediatric dental problems
• Pediatric neuromuscular disorders
• Pediatric surgery
• BMC Cancer
• Peripheral nervous system diseases
• Somatosensory disorders
• Exercise therapy
• Postural balance
• Neuromuscular adaptation
• Quality of life
• Physical activity
• Limb girdle muscular dystrophy
• Charcot Marie Tooth disease
• Hereditary motor
• Low back pain
• Health care workers
• Disabling condition
• Neuromuscular fitness
• All neuromuscular disease
• Muscle disease
• Facioscapulohumeral muscular dystrophy
• Outcome measures
• Sensori motor training
• Neuromuscular capacity
• Knee replacement
• Morphological adaptations