TAILIEUCHUNG - Ebook Clinical manual of alzheimer disease and other dementias: Part 2

(BQ) Part 2 book “Clinical manual of alzheimer disease and other dementias“ has contents: Traumatic brain injury, other causes of dementia, treatment of psychiatric disorders in people with dementia, pharmacological treatment of neuropsychiatric symptoms, supporting family caregivers, and other contents. | 9 Frontotemporal Dementia and Other Tauopathies Anne M. Lipton, ., . Adam Boxer, ., . I n its broadest sense, the term frontotemporal dementia (FTD) refers to a number of neurodegenerative diseases that vary in clinical presentation and pathological findings. FTD is also known as frontotemporal lobar degeneration (FTLD) (Neary et al. 1998). The clinical and research nosology for this disease continue to evolve and sometimes create controversy or confusion. Frontal-variant FTD (fvFTD) refers to the specific FTD clinical subtype characterized by executive dysfunction and apathy. Although the clinical syndromes vary, they characteristically involve problems with language, behavior, and/or motor findings, such Preparation of portions of this chapter was supported by National Institutes of Health Grant K23NS048855 and the John Douglas French Foundation. 219 220 Clinical Manual of Alzheimer Disease and Other Dementias as parkinsonism. Research in FTD, including genetic discoveries and the application of modern neuroimaging techniques, has led to remarkable advances. History The archetypal FTD is Pick disease, first clinically delineated by Arnold Pick (1892), who described language impairments and behavioral disturbances in the setting of focal brain atrophy. Alois Alzheimer (1911) provided the first histopathological description of Pick disease with argyrophilic inclusions (later called Pick bodies) and swollen, achromatic cells (later called Pick cells). The Lund-Manchester criteria (Lund and Manchester Groups 1994) delineated the clinical features of FTD; these criteria were later refined by a consensus panel that used the term frontotemporal lobar degeneration (Neary et al. 1998). Additional clinical consensus criteria for FTD have been published (McKhann et al. 2001). FTD occurs, on average, in individuals in their 50s and may be the most common cause of dementia in this age group (Knopman et al. 2004). Onset before age 65 years is one of the .

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