TAILIEUCHUNG - Chapter 125. Health Care– Associated Infections (Part 7)

Vascular device–related infection is suspected on the basis of the appearance of the catheter site or the presence of fever or bacteremia without another source in patients with vascular catheters. The diagnosis is confirmed by the recovery of the same species of microorganism from peripheral-blood cultures (preferably two cultures drawn from peripheral veins by separate venipunctures) and from semiquantitative or quantitative cultures of the vascular catheter tip. Less commonly used diagnostic measures include differential time to positivity (2 h) for blood drawn through the vascular access device compared with a sample from a peripheral vein or differences in quantitative. | Chapter 125. Health Care- Associated Infections Part 7 Vascular device-related infection is suspected on the basis of the appearance of the catheter site or the presence of fever or bacteremia without another source in patients with vascular catheters. The diagnosis is confirmed by the recovery of the same species of microorganism from peripheral-blood cultures preferably two cultures drawn from peripheral veins by separate venipunctures and from semiquantitative or quantitative cultures of the vascular catheter tip. Less commonly used diagnostic measures include differential time to positivity 2 h for blood drawn through the vascular access device compared with a sample from a peripheral vein or differences in quantitative cultures a 5- to 10-fold or greater step-up for blood samples drawn simultaneously from a peripheral vein and from a CVC. When infusion-related sepsis is considered . because of the abrupt onset of fever or shock temporally related to infusion therapy a sample of the infusate or blood product should be retained for culture. Therapy for vascular access-related infection is directed at the pathogen recovered from the blood and or infected site. Important considerations in treatment are the need for an echocardiogram to evaluate the patient for bacterial endocarditis the duration of therapy and the need to remove potentially infected catheters. In one report approximately one-fourth of patients with intravascular catheter-associated S. aureus bacteremia who were studied by transesophageal echocardiography had evidence of endocarditis this test may be useful in determining the appropriate duration of treatment. Detailed consensus guidelines for the management of intravascular catheter-related infections have been published and recommend catheter removal in most cases of bacteremia or fungemia due to nontunneled CVCs. When attempting to salvage a potentially infected catheter some clinicians use the antibiotic lock technique which may facilitate .

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