TAILIEUCHUNG - Results of one way bronchial valve placement in treatment of emphysema

Objectives: To evaluate the results of one-way valve placement in treatment severe emphysema in chronic obstructive pulmonary disease. Subjects and methods: This study was a prospective, randomized clinical trial and carried out on 33 stable chronic obstructive pulmonary disease (COPD) patients with localized advanced emphysema. | Journal of military pharmaco-medicine No7-2017 RESULTS OF ONE-WAY BRONCHIAL VALVE PLACEMENT IN TREATMENT OF EMPHYSEMA Dao Ngoc Bang*; Dong Khac Hung**; Ta Ba Thang*; Nguyen Quang Binh*** SUMMARY Objectives: To evaluate the results of one-way valve placement in treatment severe emphysema in chronic obstructive pulmonary disease. Subjects and methods: This study was a prospective, randomized clinical trial and carried out on 33 stable chronic obstructive pulmonary disease (COPD) patients with localized advanced emphysema. Patients underwent clinical examination, chest computed tomography (CT), measurement of FEV1, RV, TLC and Raw and arterial blood gases before and at the 3rd month after therapy. The one-way bronchial valve Zephyr was placed in lobar or segmental bronchi via flexible bronchoscopy. Results: 31 patients were placed one valve, following by one patient with two valves and one patient with 3 valves. 27 valves with the size of mm were used. The results were seen at the 3rd month after therapy that the 6-minute walk distance (6-MWD) increased in of patients more than 26 meters; CAT index decreased in of patients more than 2 points. The increase of 6-MWD and decrease of CAT and mMRC were significant in comparison with baseline and control group (p 33 (100%) 33 (100%) > ± ± ± ± > ± ± > ± ± > ± ± > p The patients in 2 groups had high mean of age with long duration of disease, low BMI and high CAT score. The ability of physical activity decreased, with the short 6-MWD ( ± meters in treatment group and ± meters in controlled group). There was no difference between 2 groups in the average age, BMI, CAT and 6-MWD. However, the patients in the group I smoked more than ones in the group II. 80 Journal of military pharmaco-medicine no7-2017 Table 2: .

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