TAILIEUCHUNG - Extraction of Lycopene from Gac Fruit (Momordica cochinchinensis Spreng) and Preparation of Nanolycopene
In this work, we extracted high purity lycopene from dried Gac (Momordica Cochinchinensis) aril using organic solvents. We also succeeded in the preparation of nanolycopene. The effect of temperature on the drying of Gac aril and suitable solvents on the extraction of lycopene has been investigated. The results showed that the suitable drying temperature for Gac aril was 60-70 oC. The suitable solvents for lycopene extraction were dichloromethane or chloroform. | Vietnam Journal of Chemistry, International Edition, 55(6): 761-766, 2017 DOI: Extraction of Lycopene from Gac Fruit (Momordica cochinchinensis Spreng) and Preparation of Nanolycopene Ho Thi Oanh1,2, Hac Thi Nhung1, Nguyen Duc Tuyen1, Le Thi Kim Van3, Trinh Hien Trung4, Hoang Mai Ha1,2* 1 Institute of Chemistry, Vietnam Academy of Science and Technology (VAST) 2 Graduate University of Science and Technology, VAST 3 National Institute of Medicinal Materials 4 School of Pharmacy, Haiphong University of Medicine and Pharmacy Received 11 October 2017; Accepted for publication 29 December 2017 Abstract In this work, we extracted high purity lycopene from dried Gac (Momordica Cochinchinensis) aril using organic solvents. We also succeeded in the preparation of nanolycopene. The effect of temperature on the drying of Gac aril and suitable solvents on the extraction of lycopene has been investigated. The results showed that the suitable drying temperature for Gac aril was 60-70 oC. The suitable solvents for lycopene extraction were dichloromethane or chloroform. The lycopene content in dried Gac aril is about %. Nanolycopene was prepared successfully by freeze-dried method, with relatively small particles size of 40-60 nm. Nanolycopene is relatively stable in the inert environment in the presence of antioxidants such as butylated hydroxytoluene (BHT). Keywords. Momordica cochinchinensis Spreng, Gac Fruit, lycopene, nanolycopene, extraction. 1. INTRODUCTION Gac fruit (Momordica Cochinchinensis Spreng) is a special fruit of Southeast Asia, especially familiar to Vietnamese people due to its high nutritional value [1-3]. Gac aril is a thin aril surrounding a gac fruit seed, containing some carotenoids (lutein, betacryptoxanthin, zeaxanthin, alpha-carotene, betacarotene, cis-lycopene, trans-lycopene, vitamin C, vitamin E, and some fatty acids (omega-3, omega6)) [4-5]. Among these carotenoids, lycopene .
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