TAILIEUCHUNG - Phytochemical and cytotoxic investigations of the lichen Stereocaulon evolutum Graewe
Lichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific metabolites with a great variety of effects such as antibiotic, antimycobacterial, antiviral, anti-inflammatory, analgesic, antipyretic and antiproliferative. As a part of searching cytotoxic compounds from lichens, a phytochemical investigation was conducted on a squamulose lichen, Stereocaulon evolutum Graewe, collected in France. | Vietnam Journal of Chemistry, International Edition, 55(4): 429-432, 2017 DOI: Phytochemical and cytotoxic investigations of the lichen Stereocaulon evolutum Graewe Vu Thi Huyen1,5, Nguyen Thi Thu Tram2,5*, Nguyen Manh Cuong3, Nguyen Phuc Dam4, Lohézic-Le Dévéhat Françoise5, Boustie Joël5 1 Department of Chemistry, Faculty of Environment, Vietnam National University of Agriculture 2 Department of Chemistry, Faculty of Science, Can Tho University of Medicine and Pharmacy 3 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology 4 Department of Chemistry, School of Education, Can Tho University 5 Team PNSCM, UMR CNRS 6226, Faculty of Pharmacy, University of Rennes 1, France Received 9 January 2017; Accepted for publication 28 August 2017 Abstract Lichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific metabolites with a great variety of effects such as antibiotic, antimycobacterial, antiviral, anti-inflammatory, analgesic, antipyretic and antiproliferative. As a part of searching cytotoxic compounds from lichens, a phytochemical investigation was conducted on a squamulose lichen, Stereocaulon evolutum Graewe, collected in France. Five known compounds including atranorin (1), atranol (2), lobaric acid (3), ursolic acid (4), and methyl 3'-methyllecanorate (5) were isolated for the first time from such lichen. Their structures were elucidated by ESI-HR-MS, NMR spectral analysis and compared with literature data. Cytotoxicity screening of five isolated compounds were evaluated on seven cell lines including HuH7, CaCo-2, MDA-MB-231, HCT116, PC3, NCI-H727 and HaCaT. Compound (5) was found high cytotoxicity effect on all investigated cell lines while other compounds showed non-cytotoxic. Keywords. Lichen, Stereocaulon, atranorin, cytotoxicity. 1. INTRODUCTION Lichens are stable, consistent and identifiable mutualistic associations between algae and/or cyanobacteria and .
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