TAILIEUCHUNG - Ebook Personalized treatment options in dermatology (E): Part 2

Part 2 book “Personalized treatment options in dermatology” has contents: Targeted therapies and biomarkers for personalized treatment of psoriasis; autoinfl ammatory syndromes - relevance to inflammatory skin diseases and personalized medicine; the personalized treatment for urticaria, and other contents. | 6 Targeted Therapies and Biomarkers for Personalized Treatment of Psoriasis Federica Villanova, Paola Di Meglio, and Frank O. Nestle Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . 77 Epidemiology, Clinical Phenotypes, and Etiopathogenesis of Psoriasis . . . . . . . 78 Immunosuppressant Therapy . . . . . . . . . . Cyclosporine . . . . . . . . . . . . . . . . . . . . . . . . Methotrexate. . . . . . . . . . . . . . . . . . . . . . . . . 81 82 82 Biologic Therapy . . . . . . . . . . . . . . . . . . . . Anti-T-Cell Therapy . . . . . . . . . . . . . . . . . . . Anti-cytokine Therapies. . . . . . . . . . . . . . . . Emerging Biologics . . . . . . . . . . . . . . . . . . . 82 82 84 84 Emerging Small Molecules . . . . . . . . . . . . 86 Concepts and Principles of Personalized Medicine: Patient Stratification and Biomarkers. . . . . . . . . . 86 Novel Technologies for Stratified Medicine in Psoriasis . . . . . . . . . . . . . . . . . 88 Biomarkers in Stratified Medicine Approaches for Psoriasis . . . . . . . . . . . . . . 90 Federica Villanova and Paola Di Meglio contributed equally F. Villanova, PhD • . Nestle, MD (*) St John’s Institute of Dermatology, King’s College London, London SE1 9RT, UK e-mail: ; P. Di Meglio, MPharm, PhD Molecular Immunology, MRC NIMR, London NW7 1AA, UK e-mail: pdmegl@ Type 0 Psoriasis Biomarkers: Markers of Disease Severity. . . . . . . . . . . . . . . . . . . . Type 1 Psoriasis Biomarkers: Drug Endotype . . . . . . . . . . . . . . . . . . . . . . . Type 2 Biomarkers: Predictive or Theranostic Biomarkers. . . . . . . . . . . . . . 91 92 93 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 Introduction Psoriasis is a complex disease, .

• Y khoa - Dược
• Personalized treatment options in dermatology
• Autoinfl ammatory syndromes
• Personalized medicine
• Clinical heterogeneity
• Bullous diseases
• Innovative therapeutics
• Personalized therapy for nonmelanoma
• Topical steroids
• Targeted therapies
• Illustrated synopsis
• Sexually transmitted diseases
• Papulosquamous disorders
• Bullous disorders
• Eczematous dermatitis
• Hurwitz clinical pediatric dermatology
• Skin disorders of childhood
• Disorders of pigmentation
• Vascular vascular disorders
• Bullous disorders of childhood
• Viral diseases of the skin
• Lasers in dermatological practice
• Connective tissue disorders
• Lymphatic system
• Lecture notes dermatology
• Inherited disorders
• Pigmentary disorders
• Vascular disorders
• Connective tissue diseases