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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cognitive flexibility in verbal and nonverbal domains and decision making in anorexia nervosa patients: a pilot study | Abbate-Daga et al. BMC Psychiatry 2011 11 162 http www.biomedcentral.com 1471-244X 11 162 BMC Psychiatry RESEARCH ARTICLE Open Access Cognitive flexibility in verbal and nonverbal domains and decision making in anorexia nervosa patients a pilot study 1 1 1 1 1 Giovanni Abbate-Daga Sara Buzzichelli Federico Amianto Giuseppe Rocca Enrica Marzola Shawn M McClintock2 3 and Secondo Fassino 1 Abstract Background This paper aimed to investigate cognitive rigidity and decision making impairments in patients diagnosed with Anorexia Nervosa Restrictive type AN-R assessing also verbal components. Methods Thirty patients with AN-R were compared with thirty age-matched healthy controls HC . All participants completed a comprehensive neuropsychological battery comprised of the Trail Making Test Wisconsin Card Sorting Test Hayling Sentence Completion Task and the Iowa Gambling Task. The Beck Depression Inventory was administered to evaluate depressive symptomatology. The influence of both illness duration and neuropsychological variables was considered. Body Mass Index BMI years of education and depression severity were considered as covariates in statistical analyses. Results The AN-R group showed poorer performance on all neuropsychological tests. There was a positive correlation between illness duration and the Hayling Sentence Completion Task Net score and number of completion answers in part B. There was a partial effect of years of education and BMI on neuropsychological test performance. Response inhibition processes and verbal fluency impairment were not associated with BMI and years of education but were associated with depression severity. Conclusions These data provide evidence that patients with AN-R have cognitive rigidity in both verbal and nonverbal domains. The role of the impairment on verbal domains should be considered in treatment. Further research is warranted to better understand the relationship between illness state and cognitive rigidity and impaired .
